The primary objective of this investigation is to compare the efficacy of Three different AF ablation strategies in patients with Persistent atrial fibrillation: CPVI plus Low-Voltage Areas ablation during sinus rhythm Versus. CPVI Plus Low-Voltage Areas Ablation During AF and CPVI alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
150
homogenization of the low voltage zones and elimination of the complex electrograms from the transitional zones during sinus rhythm
homogenization of the low voltage zones and elimination of the complex electrograms from the transitional zones during Atrial Fibrillation
ablate around the pulmonary vein orifice
The incidence of no atrial arrhythmias greater than 30 seconds
The incidence of no atrial arrhythmias greater than 30 seconds
Time frame: at least 18 months follow up
No use of antiarrhythmic drugs and no occurrence of atrial fibrillation exceeding 30 seconds
No use of antiarrhythmic drugs and no occurrence of atrial fibrillation exceeding 30 seconds
Time frame: at least 18 months follow up
No use of antiarrhythmic drugs and no occurrence of atrial tachycardia/flutter exceeding 30 seconds
No use of antiarrhythmic drugs and no occurrence of atrial tachycardia/flutter exceeding 30 seconds
Time frame: at least 18 months follow up
Atrial fibrillation load
Atrial fibrillation load
Time frame: at least 18 months follow up
Procedure time
time that the patient spend in the procedure room
Time frame: Surgical procedure
Ablation time
the total Ablation time, during CPVI and after CPVI
Time frame: 1 week after patient enrollment
Incidence of peri-procedural complications
stroke, PV stenosis, cardiac perforation, esophageal injury and death
Time frame: at least 18 months follow up
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.