The goal of this observational study focuses on the effect of different preoperative anemia status on perioperative complications in patients under moderate- to high-risk surgery. Different anemia types conclude iron-deficiency anemia(IDA), anemia of chronic disease/anemia of inflammation(ACD/AI), and combined anemia.The main question it aims to answer is whether there is a difference in the incidence of complication related to oxygen supply and demand imbalance in patients with IDA, ACD/AI or combined anemia. Patients without preoperative anemia will be recruited as the control group for secondary outcome analysis, which is whether there is a difference in the incidence of complication related to oxygen supply and demand imbalance in patients with or without anemia.
The investigators aim to screen patients according to including and excluding criteria. According to the hemoglobin level, if the patient is anemia, the investigators will offer some lab tests for serum iron, transferrin saturation, C-reactive protein to classify different anemia status. Besides, the investigators will include patients without anemia in a 2:1 ration of anemia to non-anemia. The perioperative assessment and follow-up are the same for all the included patients.
Study Type
OBSERVATIONAL
Enrollment
1,000
Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College
Wuhu, Anhui, China
RECRUITINGBeijing Longfu Hospital (Beijing Geriatric Hospital of Integrated Traditional Chinese and Western Medicine)
Beijing, Beijing Municipality, China
RECRUITINGAnesthesiology Department, Beijing NO.6 Hospital
Beijing, Beijing Municipality, China
RECRUITINGBeiJing Hepingli Hospital
Beijing, Beijing Municipality, China
RECRUITINGBeijing Puren Hospital
Beijing, Beijing Municipality, China
RECRUITINGPeking Union Medical College Hospital
Beijing, Beijing Municipality, China
RECRUITINGScience and Education Department, Zhangzhou Municipal Hospital of Fujian Province
Zhangzhou, Fujian, China
RECRUITINGDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou, China
RECRUITINGDepartment of Anesthesiology, Chifeng Municipal Hospital
Chifeng, Inner Mongolia, China
RECRUITINGDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China
RECRUITING...and 1 more locations
postoperative complications related to oxygen supply and demand imbalance
The occurrence of any of the following complications is considered a positive outcome, which include myocardial injury after non cardiac surgery(MINS), acute kidney injury(AKI), neurological damage such as stroke and delayed neurocognitive recovery(DNR)
Time frame: before discharge or until seven days after surgery
The incidence of post complications related to oxygen supply and demand imbalance in patients with or without anemia
The occurrence of any of the following complications is considered a positive outcome, which include myocardial injury after non cardiac surgery(MINS), acute kidney injury(AKI), neurological damage such as stroke and delayed neurocognitive recovery(DNR)
Time frame: before discharge or seven days after surgery
Postoperative functional disability
The World Health Organization Disability Assessment Schedule 2.0 (WHO DAS2.0) is used for disability assessment.
Time frame: 1 month, 6 months and 1 year after surgery
Cognitive function decline
The modified Telephone Interview for Cognitive Status(TICS-m) is used for cognitive function assessment.
Time frame: 1 month, 6 months and 1 year after surgery
RBC Transfusion rate
The above information can be got according to the medical record
Time frame: From date of surgery until discharge day, assessed up to 4 weeks
Length of hospital stay
The above information can be got according to the medical record
Time frame: From date of surgery until discharge day, assessed up to 4 weeks
Severe complication
Evaluated according to Clavien-Dindo classification, level three to five are defined as severe complication.
Time frame: before discharge, 1 month, 6 months and 1 year after surgery
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