Postoperative cough after pulmonary resection is a common issue seen after thoracic surgeries, hindering patients' recovery and affecting their postoperative quality of life. While vagus nerve pulmonary branch block has been known to reduce intraoperative coughing, its impact on postoperative cough post lung resection is uncertain. This study aims to assess the effects of vagus nerve pulmonary branch block on postoperative cough after VATS lung resection. A randomized controlled trial involving 104 thoracoscopic lung resection patients will assign them randomly to a vagus nerve pulmonary branch block group or a control group. The primary outcome measure is the postoperative cough incidence 3 weeks after lung resection. The secondary outcomes include assessing hoarseness in PACU, peak expiratory flow (PEF) on the first post-op day, NRS scores for cough, and LCQ-MC scores at 3 weeks post-surgery, as well as cough occurrence, NRS scores, and LCQ-MC scores at 8 weeks post-procedure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
104
Following thoracotomy, the thoracic surgeon, under direct thoracoscopic guidance, used forceps to elevate the apex of the lung, thus exposing the main trunk of the pulmonary branches of the vagus nerve. The injection needle was then advanced from a lateral-to-medial direction, and 2.5 ml of 0.375% ropivacaine was administered in close proximity to the targeted vagal branch.
Following thoracotomy, the thoracic surgeon, under direct thoracoscopic guidance, used forceps to elevate the apex of the lung, thus exposing the main trunk of the pulmonary branches of the vagus nerve. The injection needle was then advanced from a lateral-to-medial direction, and 2.5 ml of normal saline was administered in close proximity to the targeted vagal branch.
Second affiliated Hospital School of Medicine,Zhejiang University
Hangzhou, Zhejiang, China
RECRUITINGIncidence of postoperative cough following lung resection at 3 weeks post-operation
The incidence of post-lung resection cough was assessed at 3 weeks postoperatively.
Time frame: at 3 weeks post-operation
Condition of hoarseness in PACU
Assessment of hoarseness in PACU following surgery
Time frame: during in PACU, an average of 1 hour
Peak expiratory flow rate on postoperative day 1
Measurement of peak expiratory flow on postoperative day 1
Time frame: on postoperative day 1
Numerical Rating Scale for cough intensity at 3 weeks post-operation
The scale ranges from 0 to 10, with 0 indicating no cough and 10 representing the worst imaginable cough.Higher scores on the Numerical Rating Scale for cough intensity indicate a more severe cough condition.
Time frame: at 3 weeks post-operation
Leicester Cough Questionnaire for Measuring Chronic Cough at 3 weeks post-operation
The LCQ-MC score ranges from a minimum of 0 to a maximum of 21, with three dimensions: physical, psychological, and social. Each dimension is scored from 1 to 7, and the total score is the sum of the three dimensions.Higher scores on the LCQ-MC indicate better health-related quality of life. A score of 0 represents the worst possible quality of life, while a score of 21 represents the best possible quality of life in relation to cough.
Time frame: at 3 weeks post-operation
Incidence of postoperative cough following lung resection at 8 weeks post-operation
The incidence of post-lung resection cough was assessed at 8 weeks postoperatively.
Time frame: at 8 weeks post-operation
Numerical Rating Scale for cough intensity at 8 weeks post-operation
The scale ranges from 0 to 10, with 0 indicating no cough and 10 representing the worst imaginable cough.Higher scores on the Numerical Rating Scale for cough intensity indicate a more severe cough condition.
Time frame: at 8 weeks post-operation
Leicester Cough Questionnaire for Measuring Chronic Cough at 8 weeks post-operation
The LCQ-MC score ranges from a minimum of 0 to a maximum of 21, with three dimensions: physical, psychological, and social. Each dimension is scored from 1 to 7, and the total score is the sum of the three dimensions.Higher scores on the LCQ-MC indicate better health-related quality of life. A score of 0 represents the worst possible quality of life, while a score of 21 represents the best possible quality of life in relation to cough.
Time frame: at 8 weeks post-operation
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