Biomarkers in Parkinsonian Syndromes

Non-profit organization for scientific research in Parkinson's disease and related disorders200 enrolled

Overview

This is a prospective observational study to identify biomarkers in parkinson syndromes. Patients with parkinsonian syndromes at the early stages of disease will be recruited and will be followed up until their established clinical diagnosis or for at least 5 years. In this population, imaging and wet biomarkers as well as clinical data will b systematically collected.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Parkinson Disease Progressive Supranuclear Palsy Multiple System Atrophy Atypical Parkinsonism Parkinsonism

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

IΙnclusion Criteria: * Written informed consent, including consent to monitoring * Patients with Parkinsonism and disease duration \< 2 years * Patients with Parkinsonism and disease duration \> 2 years * Healthy individuals without any neurological disease Exclusion Criteria: * Drug-induced parkinsonism (eg, neuroleptics, lithium, valproic acid, metoclopramide). * Metabolic conditions related parkinsonism (eg, Wilson's disease, hypoparathyroidism). * Structural lesions on brain magnetic resonance imaging (MRI) that explain the symptoms, such as normal pressure hydrocephalus, moderate to severe chronic vascular encephalopathy, cerebral infarction, neoplasm * Other serious diseases that indicate a life expectancy of \<5 years. * Active participation in other interventional clinical studies

Outcomes

Primary Outcomes

Demographics

Age, gender, education, origin, race

Time frame: At enrolment

Family history

Family history of Parkinson's, dementia, tremor, other movement disorders, other neurological disorders

Time frame: At enrolment

Age

Age at onset in years

Time frame: At enrolment

Disease duration

Disease duration in years

Time frame: At enrolment

First motor symptom

First motor symptom time of onset

Time frame: At enrolment

First non-motor symptom

First non-motor symptom time of onset

Time frame: At enrolment

Side of onset

Side of onset of first motor symptom

Time frame: At enrolment

Staging

Hoehn and Yahr stage (H\&Y) stage (1-5, higher score indicate higher impairment)