Tributyrin: Time Course & Efficacy to Improve Health & Performance

Florida State University4 enrolled

Overview

The purpose of this study is to determine if tributyrin supplementation improves metabolite concentrations, overall health biomarkers, and performance in sedentary men and women. The study would further understand the potential usage of tributyrin as a health and performance increasing supplement through improving gut and immune health, sleep, and performance as well as reduce inflammation. Participants will supplement for tributyrin for 4 weeks and complete fecal metabolite measures, cardiovascular evaluation, sleep assessment, and exercise testing as well as provide blood samples.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

Conditions

Metabolite Concentration Gut Permeability Inflammation Sleep Performance

Interventions

CoreBiomeDIETARY_SUPPLEMENT

300 mg, once daily of tributyrin for 4 weeks

PlaceboDIETARY_SUPPLEMENT

300 mg, once daily of placebo for 4 weeks

Eligibility

Sex: ALLMin age: 30 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 30-50 years * Sedentary (\<150 minutes of aerobic exercise per week) Exclusion Criteria: * Chronic, uncontrolled metabolic, cardiovascular, gastrointestinal, or hepatic disease * Consumption of supplements known to impact the microbiome, hydration status, core temperature, or exercise performance * Experienced previous heat illness * Known injuries that limit exercise * BMI ≥ 40 kg/m\^2 * Pregnant

Locations (1)

Institute of Sports Sciences & Medicine

Tallahassee, Florida, United States

Outcomes

Primary Outcomes

Metabolite Concentration

Fecal butyrate concentration

Time frame: 2 and 4 weeks after onset of CoreBiome supplementation; 2 and 4 weeks after onset of Placebo supplementation

Secondary Outcomes

Gut permeability

Urine dual sugar absorption, Plasma sCD14

Time frame: 10 minutes before and 5 minutes prior to completion of exercise bout (i.e., mid-exercise)

Inflammation

Whole-body inflammation (IL-6 and IL-10) and gut-specific inflammation (IL-17 and IL-23)

Time frame: 10 minutes before and 5 minutes prior to completion of exercise bout (i.e., mid-exercise)

Immune cell composition

Relative proportions of serum immune cells (e.g., macrophages, neutrophils, T cells, B cells, etc.)

Time frame: 10 minutes before and 5 minutes prior to completion of exercise bout (i.e., mid-exercise)

Sleep Quality

Number of sleep disturbances

Time frame: Four weeks prior to day of exercise bout

Sleep quantity

Sleep duration

Time frame: Four weeks prior to day of exercise bout

Substrate Utilization (mid-exercise)

Respiratory exchange ratio assessment via metabolic testing during cycling exercise