Background: This investigation aims to explore efficacy of Taiwanese whole grain job's tear on muscle health and blood glucose and lipid levels in community-dwelling older adults. Methods: An open-label, 16-week, randomized controlled, cross-over trial involving participants with subject complaint of slower gait or weakness or fall in last year were recruited. The intervention group consumed Taiwanese whole grain job's tear (red job's tear) or white job's tear. Assessments included laboratory tests, functional assessments, and body composition.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
300cc drink made from red job's tear, 2 bottle/day from week 0 to week 8
300cc drink made from white job's tear, 2 bottle/day from week 0 to week 8
Taipei Veterans General hospital
Taipei, Taiwan
RECRUITINGChanges of appendicular skeletal muscle index(ASMI)
ASMI=appendicular skeletal muscle mass(kg)/(height(m)2)
Time frame: 0, 8, 16 week
Changes of handgrip strength
Maximal handgrip strength of dominant hand (kg)
Time frame: 0, 8, 16 week
Changes of gait speed
Usual gait speed measured by 6-meter walking (m/s)
Time frame: 0, 8, 16 week
Changes of time required to finish timed up and go(TUG) test
Changes of time required to finish timed up and go(TUG) test
Time frame: 0, 8, 16 week
Changes of inflammation marker
defined by hsCRP
Time frame: 0, 8, 16 week
Changes of insulin resistance
Measured by HOMA-IR
Time frame: 0, 8, 16 week
Changes of LDL
Changes of LDL
Time frame: 0, 8, 16 week
Changes of muscle biomarker 1
Measured by serum myostatin
Time frame: 0, 8 week
Changes of muscle biomarker 2
Measured by serum follistatin
Time frame: 0, 8 week
Changes of muscle biomarker 3
Measured by serum activin A
Time frame: 0, 8 week
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