Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)

China-Japan Friendship Hospital100 enrolled

Overview

The goal of this observational study is to explore the incidence and effect on prognosis of coronary microvascular dysfunction in patients present of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) \>0.80.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Angina Patients With Non-obstructive Coronary Artery Disease Coronary Microvascular Dysfunction Index of Microvascular Resistance

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * presence of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) \>0.80 Exclusion Criteria: 1. acute myocardial infarction 2. significant valvular heart disease 3. advanced chronic kidney disease 4. patients with significant epicardial coronary artery stenosis (\>70% in major vessels by diagnostic coronary angiography) needing percutaneous coronary intervention 5. patients unable to provide written informed consent

Outcomes

Primary Outcomes

MACE in 12 months

major adverse cardiovascular events 12 months, including cardiac death, myocardial infarction, and readmission for angina.

Time frame: 12 months