A Clinical Study to Evaluate the Tolerance, Pharmacokinetics and Efficacy of TQ-A3334 Tablets

Inclusion Criteria: * Understood and signed an informed consent form; * 18 years old and older; Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 1; life expectancy ≥12 weeks; * Histologically confirmed advanced non-small cell lung cancer; * Has received at least two systemic chemotherapy regimens which is failure or intolerance； * At least one measurable lesion（ based on Response evaluation criteria in solid tumors (RECIST) 1.1; * The main organs function are normally； * Male or female subjects should agree to use an adequate method of contraception starting with the first dose of study therapy through 6 months after the last dose of study (such as intrauterine devices , contraceptives or condoms) ；No pregnant or breastfeeding women, and a negative pregnancy test are received within 7 days before the randomization； * In addition to the above criteria, the extended research phase must meet the following criteria: epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are negative; or patients with positive test results of EGFR and ALK are resistant or intolerant after receiving the targeted drug treatment. Exclusion Criteria: * Small cell lung cancer * Other malignant tumors that have appeared or are presently present within 5 years, except for cured cervical carcinoma in situ and non-melanoma skin cancer * Has received chemotherapy, surgery, radiotherapy, the last treatment from the first dose less than 4 weeks, or oral targeted drugs for less than 5 half-lives, or oral fluorouracil pyridine drugs for less than 14 days, mitomycin C and nitrosourea for less than 6 weeks * Expect to use any active vaccine against infectious diseases within 28 days before the first administration or during the study period * Immunosuppressive therapy with immunosuppressive agents or systemic or absorbable local hormones (dosage \> 10 mg/day prednisone or other therapeutic hormones) is required for the purpose of immunosuppression, and is still in use for 2 weeks after the first administration * Active autoimmune diseases that require systemic treatment have occurred within 2 years before the first administration * Hypersensitivity to TQ-A3334 or its excipient * Has uncontrollable symptoms of brain metastases, spinal cord compression, cancerous meningitis * Has unrelieved toxicity reactions ≥ grade 1 due to previous treatment * Imaging (CT or MRI) shows that tumor invades large blood vessels or the boundary with blood vessels is unclear * Has thyroid dysfunction that requires drug treatment within 6 months before the first administration * Has multiple factors affecting oral medication * Has any severe acute complications before the first administration * Have participated in other clinical trials within 4 weeks before the first administration * According to the judgement of the researchers, there are other factors that may lead to the termination of the study * In addition to the above criteria, the extended research phase must meet the following criteria: 1. Pathologically diagnosed as central, hollow lung squamous cell carcinoma, or non-small cell lung cancer with hemoptysis; 2. EGFR and ALK are positive untreated with relevant targeted drugs; 3. Has received anlotinib hydrochloride capsules.