The Prognosis of Colorectal Cancer Patients After Indocyanine Green Fluorescence-guided Radical Surgery

Shanghai Tong Ren Hospital235 enrolled

Overview

Previous studies of Indocyanine green (ICG) in colorectal surgery have focused on lymphatic mapping, lymph node detection, and the number of harvested lymph nodes. However, relatively few studies have evaluated the outcomes of this imaging technology, especially the prognosis following of colorectal cancer resection. The present study assessed the prognosis of colorectal cancer patients following ICG fluorescence-guided surgery as compared to conventional surgery without the use of ICG Fluorescence imaging

Study Type

OBSERVATIONAL

Enrollment

235

Conditions

Colorectal Cancer

Interventions

ICG Guided surgeryPROCEDURE

In ICG guided surgery group,Approximately 0.3 ml of ICG dissolved in 2.5 mg/ml of sterile water was injected submucosally by the endoscopic doctors through colonoscopy at two points around the tumor.All patients underwent standard complete mesocolic excision (CME) or total mesorectal excision (TME) with curable purpose using ICG lymphangiography procedure

conventional surgeryPROCEDURE

All patients underwent standard complete mesocolic excision (CME) or total mesorectal excision (TME) with curable purpose

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \&gt; 18 years, * confirmed diagnosis of primary CRC, * preoperative tumor stage of cT1 to cT4, N-/+, M0 as determined by contrast-enhanced computed tomography (CT), * no distant metastasis, -American Society of Anesthesiologists(ASA)Physical Status Classification score of 1, 2, or 3- Exclusion Criteria: * history of previous colorectal surgery, emergent surgery, or palliative resection; * pregnancy or breastfeeding; * allergy or history of an adverse reaction to ICG; and * severe mental disorder.

Locations (1)

Shanghai Tongren Hospital

Changning, Shanghai Municipality, China

Outcomes

Primary Outcomes

disease-free survival(DFS)

the duration from radical surgery to the confirmation of recurrence or metastasis by regular or telephone follow-up

Time frame: 1 month

Secondary Outcomes

the number of harvested lymph nodes

the number of harvested lymph nodes including positive and negative ones

Time frame: 1month

Data from ClinicalTrials.gov

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