Effectiveness and Safety Comparison of Lunaphil Ultra (Hyaluronic Acid, by Espad Pharmed Co.) Versus Juvederm Ultra 4® (Hyaluronic Acid, by Allergan Co.) in Nasolabial Folds (NLFs) Management

Inclusion Criteria: * Subjects ≥ 30 years of age * Visible bilateral NLFs that were approximately symmetrical and had an equal severity ranging from moderate to severe (assessed at the deepest part) * Able to follow study instructions and likely to complete all required visits * Signed informed consent Exclusion Criteria: * History of bleeding disorders or participants receiving or recently exposed (≤ 3 weeks) to continuous treatment with thrombolytics, anticoagulants, platelet inhibitors, or NSAIDs * Acute herpetic eruption * Known susceptibility to keloid formation, hypertrophic scarring or clinically significant skin pigmentation disorders * Known sensitivity to local anesthetics of the amide type (such as lidocaine), history of hypersensitivity to gram-positive bacterial proteins, history of multiple severe allergies, history of anaphylactic shock * Known hypersensitivity to any component of the study products or excipients (like hyaluronic acid) * History of receiving immune therapy or a history of autoimmune disease * History of active chronic debilitating systemic disease * History of connective tissue disease, history of malignancy (except for non-melanoma skin cancer) within the last 5 years * Clinically significant active dermatologic disorders within the last 6 months * Use of oral retinoids, over-the-counter (OTC) or prescription antiwrinkle treatments, microdermabrasion, or chemical peels in the NLF area within the last 4 weeks or intention to use them during the study * Any prior cosmetic procedure or tissue augmentation at the NLF injection site within 1 year before study entry (or intent to undergo such a procedure during the study) * Pregnancy or breastfeeding