Fasting in the intensive care unit is a crucial issue and has been studied in particular in patients on mechanical ventilation or at the time of weaning. To date, there are no data on fasting in patients with acute respiratory failure hospitalised in the intensive care unit but not intubated. The nutritional attitude to adopt in these patients is not mentioned in the recommendations on nutrition for intensive care patients, even though it has been proven in the literature that this specific category of patients does not achieve the theoretical calorie targets, particularly as a large proportion of these patients are not fed, whether orally (or per os), enteral via a naso- or oro-gastric tube or parenterally. There is therefore a real rationale for trying to maintain a nutritional intake in patients with acute respiratory failure. One of the fears of the team caring for a patient in acute respiratory failure is the potential occurrence of false routes. In addition to false routes, orotracheal intubation of patients requiring mechanical ventilation in intensive care presents a risk of inhalation of gastric contents followed by the potential development of pneumonia. In the clinical setting, inhalation may not be symptomatic, but may progress to severe pneumonia and acute respiratory distress syndrome, pulmonary fibrosis and therefore be life-threatening. By analogy, in intensive care, patients at risk of intubation are put on a fast as a preventive measure to limit the risk of a false route and the risk of potential inhalation in the event of intubation. This practice, which is very common on admission to intensive care and continuous care units, has not been studied in the literature and is not the subject of recommendations. Finally, patients hospitalised in intensive care are subject to numerous discomforts. The hypothesis put forward is that the continuation of intravenous fluids in intensive care units for patients at risk of intubation does not increase the need for intubation and does not increase adverse effects such as false routes or inhalation of gastric contents in patients who ultimately require intubation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
754
Patients will be able to ingest liquids or solid food orally, at any frequency and in any quantity they wish, according to their tolerance, with paramedical assistance if necessary.
The patient will not be able to ingest liquids or solid food.
Intensive care, University Hospital, Blois
Blois, France
Intensive care, Hospital, Bourges
Bourges, France
Intensive care, Hospital, Colombes
Colombes, France
Intensive care, Hospital, Dreux
Dreux, France
Intensive care, Hospital, La Roche sur Yon
La Roche-sur-Yon, France
Intensive care, Hospital, Le MANS
Le Mans, France
Intensive care, Hospital, Lille
Lille, France
Intensive care, Hospital, Morlaix
Morlaix, France
Intensive care, Hospital, Nantes
Nantes, France
Intensive care, University Hospital, Orléans
Orléans, France
...and 1 more locations
Percentage of patients intubated or dying without intubation within 96 hours of randomisation
Time frame: From randomisation to 96 hours
Simple verbal scale between 1 and 4 of sensation of thirst and hunger at D1 after randomisation
Time frame: At Day 1 after randomisation
Mortality at D28
Time frame: At Day 28
Time from randomisation to intubation to Day 28
Time frame: From randomisation to day 28
Occurrence of vomiting during intubation
Time frame: Between the start and end of the intubation procedure
Immediate post-intubation salivary amylase and pepsin rates
Time frame: Immediate post-intubation
Natraemia rates within 4 days of randomisation
Time frame: From randomisation to day 4
Occurrence of acute renal failure within 4 days of randomisation
Time frame: From randomisation to day 4
Occurrence of hypoglycaemia within 4 days of randomisation
Time frame: From randomisation to day 4
Occurrence of at least one nosocomial pneumonia within 28 days of randomisation
Time frame: From randomisation to day 28
Occurrence of at least one pneumonia acquired under early mechanical ventilation
Time frame: From randomisation to day 28
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