This study will be performed to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides (MCTs)) to induce a mild ketogenic state in healthy older (60-80y), overweight/obese (BMI: 25-35 kg/m2) individuals. Since the aim is to induce a mild ketogenic state, a 25g MCT-based nutrient mix, a 25g MCT-based nutrient mix + cofactors, or a non-ketogenic control will be compared.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
11
The 25g MCT-based nutrient mix will be consumed two hours after breakfast.
The 25g MCT-based nutrient mix + cofactors will be consumed two hours after breakfast.
The non-ketogenic control will be consumed two hours after breakfast.
Maastricht University
Maastricht, Netherlands
Plasma ketone levels
The primary outcome is plasma ketone levels determined regularly over a defined time period after ingestion of the respective nutritional supplements, expressed as area under the curve (AUC).
Time frame: Testday 1, 2, and 3
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