Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients

Peking Union Medical College Hospital265 enrolled

Overview

An observational cohort was established using preoperatively collected biospecimens and prospectively ascertained postoperative outcomes. A nested case-control metagenomic analysis was subsequently conducted within the cohort, including participants with grade II or higher PPCs and selected participants without PPCs.

Study Type

OBSERVATIONAL

Enrollment

265

Conditions

Gut Microbiota Postoperative Pulmonary Complications

Interventions

Elective abdominal surgeryPROCEDURE

The included elderly patients are those who are preparing for elective abdominal surgery and the surgery time exceeds 2 hours.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: ≥ 65 years old; 2. Surgery: Major abdominal surgery (expected duration ≥ 2 hours); 3. Anesthesia methods: general anesthesia, tracheal intubation; 4. ASA classification: I-IV levels; 5. Postoperative Pulmonary Complications Risk Score (ARISCAT): Medium to High Risk 6. Patients or their families are able to understand the research protocol and are willing to participate in this study, providing written informed consent Exclusion Criteria: 1. Emergency surgery; 2. This is the second surgery within the past month; 3. Preoperative presence of pulmonary infection or other serious pulmonary complications 4. Patients who have used antibiotics, probiotics, and acid suppressants within one month before surgery

Locations (1)

Department of Anesthesiology, Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Number of participants with postoperative pulmonary complications

The primary outcome is the occurrence of one or more ppcs, including primarily hypoxemia, atelectasis, and pneumonia, etc.

Time frame: Within 7 days after surgery

Secondary Outcomes

Preoperative gut microbiome composition

Taxonomic composition and relative abundance derived from shotgun metagenomic sequencing of eligible preoperative faecal samples.

Time frame: Preoperative, before bowel preparation and prophylactic antibiotics

Concentration of inflammatory cytokines in peripheral blood before and after surgery

Inflammatory factors include high-sensitivity C-reactive protein (CRP) and procalcitonin (PCT)

Time frame: Before and within 7 days after surgery

Data from ClinicalTrials.gov

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