comparison between oral sumatriptan and Nebulized Dexmedetomidine in Post Dural Puncture Headache in Cesarean Section
A total of 48 patients will be randomly chosen to receive either inhaled dexmedetomidine (Group D, n= 24) or oral sumatriptan (Group S, n= 24) by a random sequence number generated by the computer kept in sealed envelopes. Those envelopes will be opened once the patient is recruited and participants will receive either inhaled dexmedetomidine or oral sumatriptan as per the envelope. Data collectors will be blinded to the type of used medication (Dexmedetomidine or Sumatriptan).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
48
Dexmedetomidine (Precedex) is a highly selective alpha 2 adrenoreceptor agonist which produce sedation, anxiolysis, analgesia, and decreasing inflammatory response to anaesthesia and surgical procedure.
Sumatriptan (Imigran) is a selective serotonin receptor agonist. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain (as substance -p), nausea, and other symptoms of migraine
Fayoum University hospital
El Fayoum Qesm, Faiyum Governorate, Egypt
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: First 48 hours
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: 6 hours.
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: 12 hours.
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: 18 hours.
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: 24 hours.
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: 30 hours.
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: 36 hours.
visual analogue scale
VAS Score from 0 to 10 where score 0 is no headache and 10 is the worst one
Time frame: 42 hours.
Lybecker score
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Mild Mild:Daily activities slightly restricted. Patient is not bedridden No associated symptoms Moderate:Daily activities significantly restricted and most of the day patient is bedridden with or without associated symptoms Severe:Daily activities completely restricted, patient is bedridden all the day and always with associated symptoms
Time frame: 6 hours
Lybecker score
Mild Mild:Daily activities slightly restricted. Patient is not bedridden No associated symptoms Moderate:Daily activities significantly restricted and most of the day patient is bedridden with or without associated symptoms Severe:Daily activities completely restricted, patient is bedridden all the day and always with associated symptoms
Time frame: 12 hours
Lybecker score
Mild Mild:Daily activities slightly restricted. Patient is not bedridden No associated symptoms Moderate:Daily activities significantly restricted and most of the day patient is bedridden with or without associated symptoms Severe:Daily activities completely restricted, patient is bedridden all the day and always with associated symptoms
Time frame: 18 hours
Lybecker score
Mild Mild:Daily activities slightly restricted. Patient is not bedridden No associated symptoms Moderate:Daily activities significantly restricted and most of the day patient is bedridden with or without associated symptoms Severe:Daily activities completely restricted, patient is bedridden all the day and always with associated symptoms
Time frame: 24 hours
Lybecker score
Mild Mild:Daily activities slightly restricted. Patient is not bedridden No associated symptoms Moderate:Daily activities significantly restricted and most of the day patient is bedridden with or without associated symptoms Severe:Daily activities completely restricted, patient is bedridden all the day and always with associated symptoms
Time frame: 30 hours
Lybecker score
Mild Mild:Daily activities slightly restricted. Patient is not bedridden No associated symptoms Moderate:Daily activities significantly restricted and most of the day patient is bedridden with or without associated symptoms Severe:Daily activities completely restricted, patient is bedridden all the day and always with associated symptoms
Time frame: 36 hours