This study collected data from patients with severe pneumonia to compare the duration of mechanical ventilation under different sedation regimens in real-world settings. It also evaluated and compared the sedation success rates, hemodynamic changes, and clinical outcomes of patients with severe pneumonia.
The study subjects were patients with severe pneumonia hospitalized in the Department of Respiratory and Critical Care Medicine at Xiangya Hospital, Central South University, from February 1, 2023 to December 31, 2024. Patients meeting all the following criteria were enrolled: (1) diagnosed with severe pneumonia; (2) receiving invasive mechanical ventilation and requiring continuous sedation treatment; (3) age ≥ 18 years. Patients were excluded if they met any of the following conditions: (1) allergic to routine sedative or analgesic medications; (2) had not undergone sedation-agitation assessment; (3) transferred to another hospital during treatment; (4) withdrew from active treatment or were discharged from the ICU within 72 hours after initiation of sedation. Data on patient demographics, laboratory tests, chest imaging, respiratory support methods, severity of illness assessments, sedative medication usage, and clinical outcomes were collected. The duration of mechanical ventilation under different sedation regimens in real-world settings was compared, and the correlation between sedation success rates, hemodynamic changes, and clinical outcomes in patients with severe pneumonia was evaluated and compared.
Study Type
OBSERVATIONAL
Enrollment
260
Xiangya Hospital Central South University
Changsha, Hunan, China
Mechanical ventilation duration
It was defined as the time from intubation (for patients intubated after ICU admission) or ICU admission (for patients already intubated upon ICU admission) to extubation or death, whichever occurred first.
Time frame: From intubation (or ICU admission for patients already intubated at ICU admission) until extubation or death, whichever occurs first, assessed up to 90 days.
Sedation success rate
The level of sedation was assessed using the Richmond Agitation-Sedation Scale (RASS). Successful sedation was defined as the rate of achieving the target sedation level of Richmond Agitation-Sedation Scale \[RASS\]- 1 to - 4 in more than 90% of recorded RASS assessments.
Time frame: During the continuous sedation treatment period, from the initiation to the discontinuation of continuous sedation, ICU discharge, or death (whichever comes first), assessed up to 90 days.
Length of ICU Stay
The total number of days from ICU admission to ICU discharge. For patients who die in the ICU, the length of stay is calculated as the date of death minus the date of ICU admission.
Time frame: From ICU admission up to ICU discharge or death.
28-Day Survival Rate
The proportion of patients alive at 28 days after ICU admission. Vital status was assessed 28 days after ICU admission.
Time frame: From ICU admission through day 28.
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