The T-RRex study evaluates the efficacy of WU-CART-007 for patients with Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphoblastic Lymphoma (LBL) and to WU-CART-007 as a therapy to induce complete Minimum Residual Disease (MRD) negative response
This is a Phase 2, single-arm, multi-center, open label study in patients with R/R T-ALL/LBL and T-ALL/LBL in remission but remaining MRD positive.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
125
A single IV infusion of WU-CART-007
City of Hope
Duarte, California, United States
RECRUITINGR/R Cohort - Composite Complete Response Rate
CRc is defined as proportion of patients that achieve a complete remission (CR) + CR with incomplete hematologic recovery (CRi)
Time frame: 24 months
MRD Pos Cohort - Response Rate
Defined as the efficacy of WU-CART-007 to induce complete MRD negative response
Time frame: 24 months
Allotera Therapeutics Clinical Trials Clinical Trials
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