Stroke remains one of the main socially significant problems in the healthcare in the third millennium. The lethality in persons with history of stroke by the end of the 1st year of disease is high. A trend to increased frequency of stroke in the young age is observed during the last decade; third of patients is working-age individuals, out of whom only 15-20% returns to labor, and others remain disabled persons requiring constant medical and social support
Study Type
OBSERVATIONAL
Enrollment
562
Cytoflavin solution for infusions. 20-40 ml/day (10 ml with the interval of 8-12 hours for 10 days; the single dose is increased up to 20 ml in case of the severe form of the disease) by intravenous drop infusion in dilution per 100-200 ml of 0.9% sodium chloride solution for 10 days; rate of administration: 3-4 ml/min
"Ivanovo Regional Clinical Hospital"
Ivanovo, Russia
RECRUITINGKazan State Medical University
Kazan', Russia
RECRUITINGState Autonomous Institution of Health Interregional clinical diagnostic center
Kazan', Russia
RECRUITINGMoscow City Clinical Hospital No.64 (CCH named after V.V. Vinogradov)
Moscow, Russia
RECRUITINGN.I. Pirogov City Clinical Hospital No. 1
Moscow, Russia
RECRUITINGVorohobov's City Clinical Hospital №67
Moscow, Russia
RECRUITINGCity Clinical Hospital No. 1 Novosibirsk
Novosibirsk, Russia
RECRUITINGAlexandrovskaya hospital
Saint Petersburg, Russia
RECRUITINGAlmazov National Medical Research Centr
Saint Petersburg, Russia
RECRUITINGCity Mariinsky Hospital
Saint Petersburg, Russia
RECRUITING...and 7 more locations
Percentage of patients with favorable functional outcome (score 0-2) according to Modified Rankin Scale (mRS) on Day of Discharge (assessment at Visit 4 or Visit 5, on Day of Discharge) and on Day 90;
Modified Rankin Scale (mRS)
Time frame: Base, day 14, day 21, day 90
Total score according to Modified Rankin Scale (mRS) on Day of Discharge and Day 90 in the test and control group;
Modified Rankin Scale (mRS)
Time frame: Day 14, day 21, day 90
Total score according to Rivermead Scale on Day 7, Day 14, Day 21, and Day 90 in the test and control group
Rivermead Scale
Time frame: Day 7, day 14, day 21, day 90
Change of the total score according to National Institute of Health Stroke Scale (NIHSS) on Day 3, Day 7, Day 14, and Day 21 as compared to the baseline level (Day 1);
National Institute of Health Stroke Scale (NIHSS)
Time frame: Day 7, day 14, day 21, day 90
Change of the total score according to Stroke-Specific Quality of Life Scale (SS-QOL) on Day 90 as compared to Day of Discharge;
Stroke-Specific Quality of Life Scale (SS-QOL)
Time frame: Day 14, day 21, day 90
Percentage of patients with repeated ACVA or TIA during the study;
Repeated ACVA or TIA
Time frame: Day 90
Percentage of patients with lethal outcome in the period of hospitalization and follow-up
Lethal outcome
Time frame: Day 90
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