Previously, our team compared the effects of a low-residue full nutrition formula podwer (FNFP) combined with 3 liters of polyethylene glycol(PEG) solution and the self-prepared low-residue diet combined with 3 liters of PEG solution on the quality of bowel preparation for colonoscopy, and the results showed that the adequate bowel preparation rate was significantly improved in low-residue full nutrition formula podwer group. However, there are still a considerable number of patients in the process of taking 3L PEG appeared bloating, abdominal pain, nausea, vomiting and other adverse reactions, indicating some subjects can not tolerate the dosage of 3L PEG. In order to reduce adverse reactions and provide more options for people with low PEG tolerance, this study intends to compare the effects of low-residue FNFP combined with 2L PEG and self-provided low-residue diet combined with 3L PEG on the quality bowel preparation, colonoscopy lesions detection, adverse reactions, and tolerance, compliance and satisfaction of subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
757
The day before the colonoscopy, subjects were given a low-residue full nutrition formula podwer instead of a traditional self-prepared low-residue diet. Subjects were given 6 packs (60g/pack) pre-packaged FNFP and asked to use the FNFP according to individual needs. The 2 liters of polyethylene glycol solution is taken in split dosing, with 1 liter taken at 8pm the day before the colonoscopy and 1 liter taken 3-5 hours before the colonoscopy.
Subjects in the self-prepared Low-residue diet group were instructed to follow and prepare an Low-residue diet in the day prior to colonoscopy. The 3 liters of polyethylene glycol solution is taken in split dosing, with 1 liter taken at 8pm the day before the colonoscopy and 2 liter taken 4-6 hours before the colonoscopy.
Lu'an People's Hospital
Lu'an, Anhui, China
PLA 909 Hospital
Quanzhou, Fujian, China
PLA 909 Hospital
Zhangzhou, Fujian, China
Huizhou Central People's Hospital
Huizhou, Guangdong, China
Jiangmen Central Hospital
Jiangmen, Guangdong, China
Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The First Affiliated Hospital of Hebei North University
Zhangjiakou, Hebei, China
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Nanjin, Jiangsu, China
Jiangsu Province Hospital
Nanjing, Jiangsu, China
...and 17 more locations
Adequate bowel preparation rate
Defined as score ≥ 2 for all colon segment (right-side colon, transverse colon, and left-side colon) according to the Boston Bowel Preparation Scale
Time frame: Two months
Excellent bowel preparation rate
Time frame: Two months
BBPS score (including total score, left colon, transverse colon, and right colon)
Time frame: Two months
Aronchick Scale score
Time frame: Two months
Bowel preparation completion rate
PEG intake is more than 90% of the requirement
Time frame: Two weeks
Subject satisfaction rate
Time frame: Two weeks
Colonoscopist satisfaction rate
Time frame: Two weeks
Adenoma detection rate
Time frame: Four weeks
Polyp detection rate
Time frame: Two weeks
Compliance with FNFP
Time frame: Two weeks
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