The study is being conducted to evaluate the efficacy, and safety of HRS-1893 for obstructive hypertrophic cardiomyopathy
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
42
HRS-1893
Fuwai Hospital Chinese Academy of Medical Sciences (CAMS)
Beijing, Beijing Municipality, China
The subjects' left ventricular outflow tract pressure gradient (Valsalva LVOT-G) was assessed for changes from the baseline after performing the Valsalva maneuver
Time frame: After 12 weeks of HRS-1893 treatment
Change in peak oxygen uptake (pVO2) and carbon dioxide ventilation equivalent (VE/VCO2)
Time frame: Baseline to Week 12
Change in LVEF
Time frame: Baseline to Week 12
Change in LVOT-VTI
Time frame: Baseline to Week 12
Change in LV-FS
Time frame: Baseline to Week 12
Change in LV-GLS
Time frame: Baseline to Week 12
Change in Rest LVOT-G
Time frame: Baseline to Week 12
Change in Valsalva LVOT-G
Time frame: Baseline to Week 12
Change in cardiac troponin
Time frame: Baseline to Week 12
Change in NT-proBNP
Time frame: Baseline to Week 12
Change in Kansas City Cardiomyopathy Questionnaire - Clinical Summary Score (KCCQ-CSS)
Time frame: Baseline to Week 12
Proportion of participants with ≥ 1 class improvement in NYHA Functional Class
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Time frame: Baseline to Week 12
Incidence and severity of any adverse events (AESI, SAE, TRAE, TEAE)
Time frame: Through study completion, an average of 68 weeks
plasma concentration of HRS-1893
Time frame: Through study completion, an average of 68 weeks