Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10

Cliniques universitaires Saint-Luc- Université Catholique de Louvain142 enrolled

Overview

To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors. Having such a method at our disposal would enable us to better assess the risk to develop those defects and will help us provide new prevention and treatment strategies to ensure a healthy oral development. The aims of this study are : * Assess the caries risk in childhood cancer survivors compared with a control group. * Assess the dental development defects risk in childhood cancer survivors compared with a control group.

This will be an international study comparing the Childhood Cancer Survivors (CCS) and a control group. A questionnaire will be provided to the patients to gather information. A standard of care dental examination will then take place in a dental office in the Cliniques Universitaires Saint-Luc. We also collect medical data to complete the files.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

142

Conditions

Chemotherapy Effect Dental Caries Malocclusion

Eligibility

Sex: ALLMin age: 12 YearsMax age: 36 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age below 10 at cancer diagnosis (for the CCS group). * Chemotherapy must have been used to treat the patient (For the CCS group). * The patient is 12 years old or older at the time of the follow-up appointment of the present study Exclusion Criteria: * A patient who was diagnosed and treated after 10 years old. * Patient below 12 years old at time of study recruitment * Patients with syndrome or diseases that involve teeth impairment\* * Pregnant patient * Refusal or inaptitude to undergo dental and radiographic examination

Outcomes

Primary Outcomes

Assessment of the caries experience by using the Decay Missing Filled Teeth score (DMFT)

Assess the impact of the chemotherapy agents on the risk of ulterior caries development

Time frame: Thoughout the entire study, approximately during 2 years

Secondary Outcomes

Assessment of the prevalence of dental development defects (DDD)

Assess the impact of the chemotherapy agents on the risk of ulterior dental development defect