Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery

N/ARecruitingNCT06519500

Regina Elena Cancer Institute40 enrolled

Overview

Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.

Given the need for the use of experimental models that mimic the tumor of origin

Study Type

OBSERVATIONAL

Enrollment

Conditions

Gastro-entero-pancreatic Neoplasms

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * over 18 years of age; * diagnosis of GEP-NEN carried out via histological investigation or via positivity to the uptake PET-CT with 68Ga-peptides; * availability of adequate material for the preparation of organoid cultures, derived from surgery; * written informed consent. Exclusion Criteria: * previous chemotherapy treatments

Locations (1)

"Regina Elena" National Cancer Institute

Rome, Italy

RECRUITING

Outcomes

Primary Outcomes

Set up of at least 10 organoid cultures

The organoids will be generated from tumor tissue samples and surrounding healthy tissue obtained from patients affected by GEP-NEN (who meet the inclusion/exclusion criteria) collected, according to clinical practice, during tumor resection surgery. Only the excess material after carrying out all the investigations necessary for the correct diagnosis histological analysis can be used for the purpose of the project

Time frame: 42 months

Central Contacts

Laura Monteonofrio, Doctor

CONTACT

0652665270 laura.monteonofrio@ifo.it

Data from ClinicalTrials.gov

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