Efficacy of Bupivacaine-magnesium Combination Versus Bupivacaine Alone in Genicular Nerve Block

Phase 3CompletedNCT06520475

Cairo University94 enrolled

Overview

It is proved that the addition of magnesium sulfate to local anesthetics for neuraxial anesthesia improves the quality of analgesia and prolongs the duration of anesthesia . In-vitro and in-vivo studies have demonstrated that magnesium enhances the local anesthetics effect on peripheral nerves . No previous studies were conducted on magnesium sulfate as an adjuvant to the local anesthetic in genicular nerve block. Hence, this study will be conducted to assess analgesic efficacy of magnesium sulfate when added to bupivacaine in ultrasound guided genicular nerve block

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Post Operative Pain

Interventions

genicular nerve block using bupivacaine and magnesiumPROCEDURE

The patients will receive 13 ml of 0.5% bupivacaine and 2 ml of 10% magnesium sulfate

genicular nerve block using bupivacaine and normal salinePROCEDURE

The patients will receive 13 ml of 0.5% bupivacaine and 2 ml of normal saline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologist (ASA) I or II physical status. * Between 18 and 70 years of age. * Both genders. * Patients undergoing total knee replacement surgery. Exclusion Criteria: * Patient refusal. * ASA Ⅲ and Ⅳ patients. * Known allergy to the study drugs. * Hypermagnesemia. * Central or peripheral neurological disease. * Pregnancy. * Drug or alcohol abuse. * Localized infection at the site of the block. * Bleeding disorder (platelets count less than 100,000 or international normalized ratio more than 1.4)

Locations (1)

Kasr Alaini hospital

Cairo, Egypt

Outcomes

Primary Outcomes

Numerical Rating Scale

Pain will be assessed with Numerical Rating Scale. Patients will be asked to circle the number between 0 and 10, that fits best to their pain intensity. Zero usually represents 'no pain at all' whereas the upper limit represents 'the worst pain ever possible.

Time frame: 24 hours post-operatively

Secondary Outcomes

First request for analgesia

Time frame: 24 hours post-operatively

Total opioid consumption

Time frame: 24 hours post-operatively

Patient satisfaction

Patient satisfaction will be assessed at 48 h postoperatively (0 = very dissatisfied, 2 = somewhat dissatisfied, 3 = somewhat satisfied, 4 = very satisfied)

Time frame: 24 hours post-operatively

Data from ClinicalTrials.gov

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