Cytomegalovirus (CMV) Transmission and Immune Tracking (TransmIT) Study

University of Massachusetts, Worcester

Overview

The goal of STAGE I of the CMV TransmIT Study is to determine the prevalence of CMV shedding in children up to and including 36 months of age in large group childcare centers and in staff who regularly work at the center. Participants will complete a health survey and provide one saliva sample for CMV PCR testing. In addition, infrastructure for the study will be developed (e.g. community engagement to build the network of centers, data pipelines, digital platform, sampling workflows) and participant sample collection at home will be piloted. These activities will inform the design of STAGE II.

Study Type

OBSERVATIONAL

Conditions

Cytomegalovirus Infections

Interventions

CMV PCR on salivaDIAGNOSTIC_TEST

Observational study to measure prevalence of CMV shedding by saliva PCR

Eligibility

Sex: ALLMin age: 1 DayMax age: 36 Months

Medical Language ↔ Plain English

Inclusion Criteria Children 1. All children up to and including 36 months at time of signed consent regardless of duration of attendance at the center. Children living in the same household can each be enrolled. 2. Parent(s) has provided written informed consent for the child to be screened for CMV by saliva PCR collected at the center or at home Center Staff 1. Individuals who regularly (average \>/= 5 weeks per year) work inside the center in any role, including employed, contracted, volunteer, and full or part time. 2. Staff member has provided written informed consent to be screened for CMV by saliva PCR collected at the center or at home Exclusion Criteria Children 1. \>/= 37 months of age 2. State Department of Children and Families (DCF) custody Center Staff 1. Do not regularly (average \< 5 days per year) work inside the center 2. Work associated with but not regularly inside the center (e.g. bus drivers or food delivery staff)

Locations (1)

UMass Chan Medical School

Worcester, Massachusetts, United States

Outcomes

Primary Outcomes

Prevalence of CMV shedding

Prevalence of CMV shedding in children and childcare center staff. Shedding measured by CMV PCR on saliva.

Time frame: Stage I up to 2 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.