Prevalence of Faecal Bacteriophage in Patients With Digestive Symptoms

Central Hospital, Nancy, France300 enrolled

Overview

Define the prevalence of fecal phage carriage in individuals with digestive symptoms (i) Determine the concentrations of infectious fecal phages in the stools of individuals with digestive symptoms (detection by culture) (ii) Determine fecal phage genome concentrations in the stools of individuals with digestive symptoms (PCR detection) (iii) Explore factors that could impact fecal phage carriage (patients with digestive symptoms vs. healthy individuals, immunocompromised patients vs. immunocompetent patients)

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Gastroenteritis

Interventions

bacteriophage detectionOTHER

bacteriophage detection

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 18 and 60. * Persons having developed gastrointestinal symptoms justifying microbiological stool testing at the time of hospitalization. * Person having received full information on the organization of the research and not having objected to the use of this data Exclusion Criteria: * Persons covered by articles L. 1121-5, L. 1121-7 and L1121-8 of the French Public Health Code. * Pregnant or breast-feeding women, * Minors (not emancipated), * Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice), * Persons of full age who are unable to give their consent. * Persons deprived of their liberty by a judicial or administrative decision, persons under psychiatric care by virtue of articles L. 3212-1 and L. 3213-1.

Locations (1)

CHRU Nancy

Nancy, France

Outcomes

Primary Outcomes

prevalence of faecal phage carriage

define the prevalence of faecal phage (coliphage) carriage in individuals presenting with digestive symptoms.

Time frame: baseline

Secondary Outcomes

concentrations of infectious fecal phages

Determine the concentrations of infectious fecal phages in the stools of individuals with digestive symptoms (detection by culture)

Time frame: baseline

fecal phage genome concentrations

determine fecal phage genome concentrations in the stools of individuals with digestive symptoms (PCR detection)

Time frame: baseline

Central Contacts

Cédric Hartard

CONTACT

0383153046 c.hartard@chru-nancy.fr

Data from ClinicalTrials.gov

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