This international multicentre retrospective cohort study aims to research anastomotic leakage after colon cancer resection and has two main objectives: 1. To identify predictive factors associated with 90-day mortality and 90-day Clavien-Dindo grade 4-5 complications amongst patients who developed AL following colon cancer resection and to develop and validate a prediction model for predicting 90-day mortality as well as the co-primary composite endpoint Clavien-Dindo grade 4-5 complications. 2. To explore and compare the effectiveness of various treatment strategies for AL following colon cancer resection, considering patient, tumour, resection and leakage characteristics.
Study Type
OBSERVATIONAL
Enrollment
2,000
The prediction model and comparison of various treatment strategies will be studies when the data is available for analysis.
90-day mortality
mortality correlated with anastomotic leakage
Time frame: 90 days after colon cancer resection
90-day Clavien-Dindo grade IV - V complications
This composite co-primary outcome consists of single-organ failure (i.e. grade IV) and mortality (i.e. grade V)
Time frame: 90 days after colon cancer resection
Time from colon cancer resection to diagnosis of anastomotic leakage
Time frame: at least one year follow up
Time from colon cancer resection to primary treatment of anastomotic leakage
Time frame: at least one year follow up
Length of hospital/intensive care unit stay
Time frame: at least one year follow up
Mortality
Time frame: 30-day, 90-day and one-year after colon cancer resection
Stoma presence (and if so, type of stoma)
Time frame: At least one year after colon cancer resection, preferably last date of follow up
Disease status
Time frame: At least one year after colon cancer resection, preferably at last date of follow up
Number of radiologic and surgical reinterventions
Time frame: One year after colon cancer resection
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