The goal of this observational study is to search for accurate diagnoses for patients with chronic diarrhea and assess the prevalence of microscopic colitis. The main question\[s\] it aims to answer \[is/are\]: Does microscopic colitis account for a significant portion of patients with chronic diarrhea? Participants will subjected to: * Routine laboratory examination. * Colonoscopy: A total colonoscopy will be done with visualization of the terminal ileum. Biopsies will be taken from each segment of the colon and any abnormal appearing areas, the right-sided colon (cecum, ascending colon, and transverse colon), the left-sided colon (descending colon and sigmoid colon), and the rectum.
Study Type
OBSERVATIONAL
Enrollment
116
Zagazig University Hospital
Zagazig, Sharqia Province, Egypt
Number of Participants with Chronic Diarrhea Diagnosed with Microscopic Colitis
Diagnostic criteria for the diagnosis of microscopic colitis include increased chronic inflammatory infiltration in the lamina propria, increased intraepithelial lymphocytes (IELs), degeneration of surface epithelium, and increased mitosis in crypts.
Time frame: 6 weeks
Rate of Lymphocytic and Collagenous Types of Microscopic Colitis in Individuals Experiencing Chronic Diarrhea
Over 20 IELs per 100 inter-cryptal epithelial cells (normal \<1-5/100) were required for the diagnosis of lymphocytic colitis. For collagenous colitis, subepithelial collagen band thickness was measured by ocular micrometer in specimens stained with Masson's Trichrome. Specimen thickness over 10 μm was required for the diagnosis.
Time frame: 2 weeks
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