The aim of this study is to analyze the effect of enriched formula with omega-3 in the 30-day incidence infection and inflammatory response following lung resection surgery in lung cancer patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
310
Omega-3 (4.2 g), administered through an enteral feeding tube, three days before surgery
Omega-3 (4.2 g), orally administered enriched nutritional formula, drinking at home three days before surgery
Enteral formula without omega-3 administered through an enteral feeding tube, three days before surgery
National Institute of Respiratory Diseases
Mexico City, Mexico
RECRUITING30-day incidence infection
Incidence of infectious complications after surgery diagnosed using any of these criteria: Infection of surgery wound confirmed by culture Infection confirmed by blood culture Pneumonia developed after surgery confirmed by chest x Ray.
Time frame: 30-day incidence infection following lung resection in lung cancer patients.
Changes in prostaglandin E2
Measured in serum sample made by Enzyme-linked immunosorbent assay (ELISA).
Time frame: At the beginning of nutritional therapy and at day-4 following surgery
Changes in Interleukin-6
Measured in serum sample made by Enzyme-linked immunosorbent assay (ELISA).
Time frame: At the beginning of nutritional therapy and at day-4 following surgery
Changes in Tumor Necrosis Factor Alpha (TNF-α)
Measured in serum sample made by Enzyme-linked immunosorbent assay (ELISA).
Time frame: At the beginning of nutritional therapy and at day-4 following surgery
Number of participants with therapeutic antibiotics prescription
Frequency of therapeutic antibiotics prescription will be collected from medical records and medication administration registers.
Time frame: During the hospital stay until 30-day
Hospital lenght of stay
Number of calendar days that elapsed since hospital admission to the day of hospital discharge
Time frame: During the hospital stay until 90-day
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Oral nutritional supplement without omega-3 orally administered, drinking at home three days before surgery