The diagnosis of chronic pain currently lacks objective and quantifiable biomarkers. This study aims to observe the EEG characteristics of patients with chronic pain following spinal cord injury and subsequently administer analgesic interventions with remifentanil, esketamine, flurbiprofen, and spinal cord stimulation. The correlation between EEG features and pain intensity will be examined. The research aims to advance the objectification of chronic pain diagnosis and treatment.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
60
Continuous intravenous infusion of esketamine at a dose of 0.2 mg/(kg · h). Collect resting-state EEG data and NRS scores 40 minutes after administration.
The plasma drug concentrations of remifentanil were set at 0.5 ng/ml, 1 ng/ml, and 1.5 ng/ml. After each plasma drug concentration reached a steady state, the NRS scores were assessed, and resting-state EEG was recorded for at least 5 minutes.
Single intravenous injection of Flurbiprofen at a dose of 100 mg. Collect resting-state EEG data and NRS scores 10 minutes after administration.
Beijing Tiantan Hospital
Beijing, China
EEG Spectral Characteristics
EEG power spectrum characteristics of chronic pain in patients with spinal cord injury under esketamine, remifentanil, flurbiprofen administration and spinal cord stimulation, including the δ, θ, α, β, and γ frequency bands. administration, including the δ, θ, α, β, and γ frequency bands.
Time frame: During the trial(up to 3 hours for each subject).
Numeric Rating Scale(NRS)
Numerical Rating Scale Assessment Pre- and Post-Analgesic Treatment. The NRS ranges from 0 to 10, with 0-3 indicating mild pain, 4-6 indicating moderate pain, and 7-10 indicating severe pain.
Time frame: During the trial(through study completion, 7 days)
Generalized Anxiety Disorder(GAD-7)
The GAD-7 scale ranges from 0 to 21 points, with a higher score indicating a higher level of anxiety.
Time frame: During the trial(through study completion, 7 days)
Patient Health Questionnaire-9(PHQ-9)
The PHQ-9 scale ranges from 0 to 27 points, with a higher score indicating a higher level of depression.
Time frame: During the trial(through study completion, 7 days)
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Collect resting-state EEG data and NRS scores with the spinal cord stimulator both turned off and on.
Collect resting-state EEG data and NRS scores.