Safety and Efficacy of Anti-CD20/CD30 CAR-T Cells in Subjects with Relapsed/Refractory Lymphoma

Inclusion Criteria * Patients must meet all of the following criteria to be eligible for the study: 1. Voluntarily participate in the clinical study. The individual or the legal guardian fully understands the study, sign the informed consent form (ICF), and is willing and able to follow and complete all trial procedures. 2. Age ≥ 14 years and \< 70 years. 3. Subjects with refractory or relapsed disease after current standard treatments (including allogeneic or autologous hematopoietic stem cell transplantation) who are not suitable for other treatment options, such as a second stem cell transplant. The definitions of relapsed/refractory lymphoma include one of the following situations: 1. No response to first-line treatment (primary refractory disease, excluding participants intolerant to first-line treatments). * Disease progression (PD) as assessed after first-line treatment. * Best efficacy of first-line treatment (e.g., 4 cycles of RCHOP) as stable disease (SD), with the duration of SD not exceeding 6 months after the last dose. 2. No response to second-line or more treatments. * PD being the best response to the most recent treatment. * Best efficacy of the last line of treatment as SD after at least 2 cycles, with the duration of SD not exceeding 6 months after the last dose. 3. Refractory after autologous stem cell transplant (ASCT). * Disease progression or relapse ≤ 12 months post-ASCT (relapsed patients must have biopsy-proven relapse). * If salvage treatment is administered after ASCT, the subjects must not have had a response or relapse after the last line of treatment. * Relapsed or refractory disease after two or more lines of systemic treatment. 4. Lymphoma patients must have target antigens meeting the following criteria: 1. CD20/CD30 double-positive expressing lymphoma. 2. Relapse after receiving anti-CD19-CAR-T cell therapy, with CD20 positive lymphoma. 3. CD20 positive lymphoma that has not previously received anti-CD19-CAR-T cell therapy. 4. CD30 positive Hodgkin lymphoma. 5. Subtypes of lymphoma included for enrollment are as follows: 1. DLBCL-NOS (diffuse large B-cell Lymphoma, not otherwise specified) 2. Primary mediastinal B-cell lymphoma (PMBCL) 3. Transformed follicular lymphoma (TFL), previously treated for follicular lymphoma and then transformed to refractory DLBCL 4. Mantle cell lymphoma 5. High-grade B-cell lymphoma 6. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) 7. Hodgkin lymphoma (HL) 6. ECOG performance status ≤ 2. 7. Expected survival of at least 12 weeks. 8. Adequate venous access (for apheresis) and no other contraindications for blood cell separation. 9. Laboratory tests during screening must meet the following requirements, and the hematological assessment must not have received cell growth factors within 7 days (long-acting colony-stimulating factors (G-CSF/PEG-CSF) require a 2-week interval) or platelet transfusions: 1. Absolute neutrophil count ≥ 1.0×10\^9/L. 2. Hemoglobin ≥ 60 g/L (without red blood cell transfusion in the last 7 days). 3. Platelets ≥ 50×10\^9/L (unrestricted for CLL indications). 4. Total bilirubin ≤ 1.5× the upper limit of normal (ULN); or total bilirubin ≤ 3× ULN when the tumor invades liver tissue. 5. Aspartate transaminase (AST), alanine transaminase (ALT) ≤ 2.5×ULN, with AST/ALT ≤ 5×ULN when the tumor invades liver tissue. 6. Creatinine \< 1.5× ULN and estimated creatinine clearance ≥ 60 mL/min. 10. Ejection fraction ≥ 45%, with echocardiogram (ECHO) confirming no pericardial effusion (excluding small or physiological amounts), and electrocardiogram results with no clinical significance. 11. Baseline oxygen saturation \> 92% without supplemental oxygen. 12. Women of childbearing potential must have a negative serum or urine pregnancy test result (women who have undergone surgical sterilization or have been postmenopausal for at least 2 years are not considered of childbearing potential). Exclusion Criteria: * Subjects are not eligible to participate in this study if they meet any of the following criteria: 1. MRI of the brain shows evidence of central nervous system lymphoma; active primary central nervous system DLBL, unless central nervous system involvement has been effectively treated (i.e., participant is asymptomatic), and there has been more than a 4-week gap since local treatment. 2. Active central nervous system diseases, such as epilepsy, cerebrovascular ischemia/hemorrhage, dementia, cerebellar diseases, or any autoimmune diseases with central nervous system involvement. 3. History of or concurrent diagnosis of malignancies other than CD19+ malignancies. 4. Clinically significant heart disease or arrhythmias that cannot be controlled with medication. 5. Presence or suspicion of fungal, bacterial, viral, or other infections that are uncontrolled or require intravenous antibiotics for treatment; uncomplicated urinary tract infections and uncomplicated bacterial pharyngitis are allowed. 6. Positive for hepatitis B (HBsAg positive and HBV DNA \>1000 copies/mL) and hepatitis C (positive for HCV antibodies); syphilis or human immunodeficiency virus (HIV) infection. 7. Presence of any indwelling catheter or drainage tube (such as percutaneous nephrostomy, indwelling Foley catheter, bile drainage tube, or pleural/peritoneal/pericardial catheter); use of specialized central venous access devices like Port-A-Cath® or Hickman® catheters is allowed. 8. History of using any of the following medications: 1. Lenalidomide within 1 day before the apheresis. 2. Idelalisib (oral PI3Kδ inhibitor) within 2 days before the apheresis. 3. Short-acting targeted therapy (like tyrosine kinase inhibitors) within 72 hours before the apheresis. 4. Venetoclax (BCL-2 inhibitor) within 4 days before the apheresis. 5. Long-acting growth factors (like pegylated filgrastim) within 14 days before the apheresis, or short-acting growth factors or mobilization agents (like G-CSF/filgrastim, plerixafor) within 5 days before the apheresis. 6. Pharmacological doses of corticosteroids (\>5mg/day of prednisone or equivalent doses of other corticosteroids) or other immunosuppressive agents within 7 days before enrollment. 7. Radiation therapy within 14 days before enrollment. 8. Systemic cytotoxic drugs, including low-dose maintenance chemotherapy (cyclophosphamide, ifosfamide, bendamustine, methotrexate, or mercaptopurine, vincristine, etc.), within 14 days before enrollment. If bridging therapy is given after apheresis, there should be more than a 7-day gap between bridging therapy and CAR-T cell infusion. 9. Anti-PD1 or anti-PDL1 within 4 weeks prior to enrollment. 10. Live vaccines within 4 weeks prior to enrollment. 11. Donor lymphocyte infusion (DLI) within 4 weeks prior to enrollment. 12. Immune stimulation or immunosuppressive therapy (like interferon-α, interferon-β, IL-2, etanercept, infliximab, tacrolimus, cyclosporine, or mycophenolate mofetil) within 4 weeks prior to enrollment. 13. Use of clofarabine or cladribine within 3 months prior to enrollment, or use of PEG-asparaginase within 3 weeks prior to enrollment. 9. Active graft-versus-host disease (GVHD) rated ≥2 on the CIBMTR acute GVHD grading system or requires systemic steroids at doses greater than physiological levels. 10. A history of autoimmune diseases in the past 2 years (like Crohn's disease, rheumatoid arthritis, or systemic lupus erythematosus) that has caused damage to end organs or requires systemic immunosuppression/systemic disease-modifying agents. 11. A history of myocardial infarction, cardiac angioplasty or stenting, unstable angina, or other clinically significant heart diseases within the 12 months prior to enrollment. 12. A history of genetic syndromes associated with bone marrow failure, such as Fanconi anemia, Kostmann syndrome, or Schwachman-Diamond syndrome. 13. A history of symptomatic deep vein thrombosis or pulmonary embolism requiring systemic anticoagulation in the 6 months before enrollment. Subjects need to be on preventive anticoagulant medication. 14. A history of other malignancies (except for non-melanoma skin cancer, in situ breast/cervical cancer, and other malignant tumors that have been effectively controlled without treatment in the past five years). 15. Use of other investigational medicinal products within 30 days prior to screening. 16. Pregnant or breastfeeding women of childbearing age. Women who have undergone surgical sterilization or are postmenopausal for at least 2 years are not considered of childbearing potential. 17. Male and female subjects unwilling to practice contraception from the time they agree to treatment until 12 months after completing the lymphodepleting chemotherapy or CAR-T infusion (whichever is longer). 18. Any medical activities that could interfere with the safety or efficacy evaluation of the study treatment. 19. In the judgment of the investigator, subjects are unlikely to complete all required study visits or procedures (including follow-ups) or to comply with the study participation requirements.