Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury

healthy volonteers group: Inclusion Criteria * Male or Female * Age 18 to 75 * free of central or peripheral nervous system trauma * Having given free and informed consent * Beneficiary of or affiliated to a social security scheme Exclusion Criteria: * Pregnant or breast-feeding women * Person under guardianship or curatorship * Diagnosis of a neurological disorder * Diagnosis of a psychiatric disorder * Diagnosis of a neurodegenerative disease Spinal Cord injury patients group: Inclusion Criteria:- Male or female * Aged 18 to 75 * Beneficiary of or affiliated to a social security scheme * Having suffered within 6 hours a trauma with an acute LME confirmed according to the following characteristics: * Lesion located at C4-T12 level and radiologically documented (CT scan and/or spinal MRI performed within 6 hours) * Complete or incomplete according to the American Spinal Injury Association impairment scale (ASIA A to D) * Signed consent for emergency and continuation of study Exclusion criteria: * Pregnant or breast-feeding patient * Absence of consent from the volunteer or his/her trusted support person * Patient under guardianship or trusteeship * Brain injury due to cranioencephalic trauma with a Glasgow score of less than 14 on reassessment, associated with a cerebral CT scan of grade III or less on the Marshall classification * Presence of another neurological or mental disorder or neurodegenerative disease Brain injury patients Group: Inclusion criteria: * Male or female * Aged 18 to 75 * Have suffered a traumatic brain injury (TBI) with a proven acute brain injury according to the following characteristics: * Glasgow score less than 13 on admission without metabolic cause in the context of head trauma * Cerebral CT scan at least grade II according to Marshall classification * Absence of traumatic spinal lesion threatening the integrity of the spinal canal assessed by neuroradiological examination (CT and/or MRI) * Signed consent for emergency and continuation of study * ASIA E score Exclusion criteria: * Pregnant or breast-feeding patient * Absence of consent from the volunteer or his/her trusted support person * Patient under guardianship * ASIA score A to D * Presence of another neurological or mental disorder or neurodegenerative disease