VH3739937 Phase 1 Multiple Ascending Dose (MAD) Study in Healthy Volunteers Including Relative Bioavailability (RBA), Optional Food Effect (FE), and Drug-drug Interaction (DDI)

Inclusion Criteria: 1. Participants who are overtly healthy as determined by the Investigator or medically qualified designee based on a medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring (history and ECG). 2. Participants who can understand and comply with protocol requirements and timetables, instructions, and protocol-stated restrictions. Age 3. Participant must be 18 to 55 years of age inclusive, at the time of signing the informed consent. Weight 4. Body weight \>=50.0 kg (110 lbs) for men and \>=45.0 kg (99 lbs) for women, and BMI within the range 18.5 to 32.0 kg/m2 (inclusive). Sex 5. Participants male at birth and participants female at birth: 1. Participants male at birth: Participants male at birth are eligible to participate if they agree to the following during the study intervention period and for at least 90 days (a spermatogenesis cycle) after the last dose of study intervention: • Refrain from donating sperm PLUS either: • Be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long term and persistent basis) and agree to remain abstinent. OR • Must agree to use contraception as detailed below: Agree to use a male condom and, if their partner is a person who is able to become pregnant, and who is not currently pregnant, they should also be advised of the benefit for their partner to use a highly effective method of contraception when having sexual intercourse, as a condom may break or leak. 2. Participants female at birth: A participant who was female at birth is eligible to participate if they are not pregnant or breast- / chest- feeding, and one of the following conditions applies: • They are a PONCBP as defined in Section 10.4 Contraception and barrier guidance. The Investigator is responsible for review of medical history, menstrual history/postmenopausal status, and recent sexual activity to decrease the risk for inclusion of a woman with an early undetected pregnancy. Informed consent 6. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICF and in the protocol. Exclusion Criteria: Medical conditions 1. History or presence of cardiovascular, respiratory, hepatic, renal, GI, endocrine, hematologic, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study intervention or interfering with the interpretation of data. 2. Unstable liver disease known biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones or otherwise stable chronic liver disease per Investigator assessment). 3. Known history of cirrhosis with or without viral hepatitis co-infection. 4. History of clinically relevant hepatitis within last 6 months. 5. Patients with chronic hepatitis B (HBsAg positive) infection (see HBV diagnostic criteria described below and in the study laboratory manual). 6. Have a history of malignant neoplasm (excepting definitively treated non-melanoma skin cancer or carcinoma in situ of the uterine cervix, which may be enrolled at any time) within the last 5 years. 7. Clinically significant cardiovascular disease. 8. A sustained semi-supine systolic blood pressure \>150 mm Hg or \<90 mm Hg or a semi-supine diastolic blood pressure \>95 mm Hg or \<50 mm Hg at Screening or Check-in. 9. A resting HR of \<50 bpm or \>100 bpm when vital signs are measured at Screening or Check-in. A HR from 100 bpm to 110 bpm can be rechecked by ECG or vital signs within up to 2 hours to verify eligibility. 10. An uninterpretable ECG or any significant arrhythmia or ECG finding which, in the opinion of the Investigator or VH/GSK Medical Monitor, will interfere with the safety of the individual participant. 11. Abnormalities on Screening ECG is allowed for eligibility determination: QTcF \> 450 msec., QRS \> 120 msec, PR \> 220 msec 12. Any history of significant underlying psychiatric disorder, in the opinion of the Investigator or Medical Monitor; or a clinical assessment of suicidality based on the responses on the C-SSRS (Columbia Suicidality Scale). Participants' history of suicidal behaviour and/or suicidal ideation should be considered when evaluating for suicide risk. 13. Any history of major depressive disorder with or without suicidal features, or anxiety disorders that required medical intervention such as hospitalization or other inpatient treatment and/or chronic (\>6 months) outpatient treatment. Participants with other conditions such as adjustment disorder or dysthymia that have required shorter term medical therapy (\<6 months) without inpatient treatment and are currently well-controlled clinically or resolved may be considered for entry after discussion and agreement with the VH/GSK Medical Monitor. 14. Any pre-existing physical or other psychiatric condition which could interfere with the participant's ability to comply with the dosing schedule and protocol evaluations or which might compromise the safety of the participant. 15. Current or chronic history of liver disease or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones). 16. A pre-existing condition, that could interfere with normal GI anatomy or motility hepatic and/or renal function, that could interfere with the absorption, metabolism, and/or excretion of the study interventions or render the participant unable to take oral study intervention. Prior/Concomitant therapy 17. Past or intended use of over-the-counter or prescription medication within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to dosing and for the duration of the study. 18. Use of narrow therapeutic index drugs that are substrates of P-gp or CYP3A are not permitted during the study. 19. Participants receiving any protocol-prohibited medication and who are unwilling or unable to switch to an alternate medication. Prior/Concurrent clinical study experience 20. Participation in the clinical study would result in loss of blood or blood products in excess of 500 mL within 56 days. 21. Exposure to more than 4 new chemical entities within 12 months prior to the first dosing day. 22. Current enrollment or past participation in another investigational clinical study in which an investigational intervention was administered within the last either 28 days, 5 half-lives of the test agent, or twice the duration of the biological effect of the test agent. 23. Past or current enrollment or past participation in earlier parts of this clinical study. Diagnostic assessments 24. Positive pre-enrollment clinical study drug/alcohol screen, including tetrahydrocannabinol. 25. Positive HIV fourth generation test. 26. Urine cotinine levels indicative of smoking or history or regular use of tobacco- or nicotine-containing products within 6 months prior to Screening and at admission. 27. Any acute laboratory abnormality at Screening, which would preclude the participant's participation in the study of an investigational compound. 28. Any verified Grade 4 laboratory abnormality. 29. ALT \>1.5 ULN or total bilirubin \>1.5 ULN. Participants with Gilbert's syndrome can be included with total bilirubin \>1.5xULN as long as direct bilirubin is \<1.5xULN. 30. eGFR of \<60 mL/min/1.73 m2 via CKD-EPI \[Delgado, 2022\]. 31. Presence of HBsAg at Screening or within 3 months prior to first dose of study intervention. 32. Positive hepatitis C antibody test result at Screening or within 3 months prior to first dose of study intervention. 33. Positive hepatitis C RNA test result at Screening or within 3 months prior to first dose of study intervention. Other exclusion criteria 34. Regular alcohol consumption within 6 months prior to the clinical study. 35. Regular use of known drugs of abuse, including tetrahydrocannabinol. 36. Regular use of combustible tobacco products, and non-combustible nicotine delivery systems. 37. Sensitivity to heparin or heparin-induced thrombocytopenia. 38. Sensitivity to any of the study interventions, or components thereof, or drug or other allergy that contraindicates participation in the clinical study. 39. Use of any products intended to treat medical conditions that are not approved by the governing health authority in a given country or region. 40. To assess any potential impact on participant eligibility with regard to safety, the Investigator must refer to the IB and supplements, approved product labels, and/or local prescribing information for detailed information regarding warnings, precautions, contraindications, AEs, drug interactions, and other significant data pertaining to the study drugs.