This project is a multicenter observational study that establishes a longitudinal cohort of patients with Alzheimer's disease and other dementias based on neuroimaging, molecular imaging, biological and digital markers to explore new solutions such as dementia disease mechanism, diagnosis, condition evaluation, and prognosis assessment.
This project will build a longitudinal database based on multimodal MRI imaging information of dementia subjects, various body fluid or digital markers, and a cohort. The convolutional neural network algorithm will be used to explore the imaging characteristics of healthy controls, AD, FTD, and DLB, develop an early prediction model for degenerative dementia, and achieve early differential diagnosis of different dementia subtypes. This study further performed GE180, ASEM, and exendin-4 radionuclide imaging on some subjects who completed conventional PET (AV45, Tauvir, and FDG) imaging to explore the diagnostic efficacy of these three probes as new diagnostic probes for early AD. In addition, through longitudinal follow-up of Aβ-positive MCI patients, multimodal MRI and PET image fusion technology were used to explore the changes in fused images during their conversion to AD in order to obtain early and accurate diagnostic markers.
Study Type
OBSERVATIONAL
Enrollment
1,000
Chinese People's Liberation Army General Hospital
Beijing, Beijing Municipality, China
RECRUITINGFirst Affiliated Hospital of Zhejiang University School of Medicine
Hanzhong, Hangzhou, China
RECRUITINGThe change of incidence of cognitive impairment
Number of participants who covert to AD or mild cognitive impairment (MCI) will be recorded to calculate the incidence.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of Mini-Mental State Examination (MMSE)
MMSE is a brief screening instrument used to assess cognitive function (orientation, memory, attention, ability to name objects, follow verbal/written commands, write a sentence, and copy figures) in elderly participants. Total score ranges from 0 to 30; lower score indicates greater disease severity.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of Montreal cognitive assessment-Basic (MoCA)
MoCA is a brief screening instrument used to assess cognitive function (orientation, memory, attention, ability to name objects, follow verbal/written commands, write a sentence, and copy figures) in elderly participants. Total score ranges from 0 to 30; lower score indicates greater disease severity.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of Auditory verbal learning test (AVLT)
AVLT is a screening instrument used to assess the function of memory. The score in long-term memory (N5) ranges from 0 to 12, with lower scores indicating greater disease severity.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of structural MRI
Structural MRI data will be acquired and analyzed through high-resolution T1-weighted MRI and diffusion tensor imaging (DTI).
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of functional MRI
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Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
Cangzhou, Hebei, China
RECRUITINGThe Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
RECRUITINGQilu Hospital of Shandong University, Qingdao Branch
Qingdao, Shandong, China
RECRUITINGRuijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
RECRUITINGXinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
RECRUITINGThe First Affiliated Hospital of China Medical University
Shenyang, Shenyang, China
RECRUITINGFunctional MRI data will be acquired and analyzed through blood oxygenation level dependent (BOLD) imaging.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of magnetic susceptibility
Magnetic susceptibility data will be acquired and analyzed through quantitative susceptibility mapping (QSM)
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of perfusion MR imaging
Perfusion imaging data will be acquired and analyzed through arterial spin labeling (ASL).
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
Positron emission tomography (PET)-MRI
Including AV45-PET, FDG-PET, Tau-PET, GLP-1R PET, Cholinergic receptor probe (ASEM) PET will be used to detect the amyloid, Tau burden and AD related GLP-1R as well as Cholinergic receptor change
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of blood biomarker
Blood serum p-tau 181, p-tau 217, Aβ40, pEAβ3-42 and Aβ42 , GFAP, NFL at baseline will be tested. The higher blood p-tau is a strong predictor for AD.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of speech information
Voice data collection, use a voice recorder to collect the patient's description of "stealing biscuit map" language, and save it in SWV format. And use self-developed ASR speech analysis software (China software copyright number: 2016RS164680) for speech analysis.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of Activities of daily living (ADL)
ADL is a scale used in healthcare to refer to people's daily self-care activities. Eight factors are rated to produce an overall score on a point scale of 0 to 100. The lower the score the more independence in living.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of Geriatric Depression Scale (GDS)
GDS is a neuropsychological scale used to assess the level of depression. The total score ranges from 0 to 30, with higher scores indicating greater disease severity.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year
The change of electroencephalogram (EEG)
Electroencephalogram (EEG) is used to measure electrical activity in the brain using small, metal discs (electrodes) attached to the scalp. Recorded frequencies include alpha, beta, delta and theta band power. The EEG signatures of people with cognitive impairment will be further analyzed, and its longitudinal changes will be observed.
Time frame: baseline, 1 year, 2 year, 3 year, 4 year