The purpose of this study is to assess the drug levels and safety of golcadomide (BMS-986369) in adult participants with moderate and severe Hepatic Impairment (HI), and in matched healthy control participants with normal hepatic function.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
29
Specified dose on specified days
Local Institution - 0001
Chandler, Arizona, United States
Local Institution - 0002
Orlando, Florida, United States
Texas Liver Institute
San Antonio, Texas, United States
Maximum observed plasma concentration (Cmax)
Time frame: Up to approximately 44 days
Time of maximum observed plasma concentration (Tmax)
Time frame: Up to approximately 44 days
Area under the plasma concentration-time curve from time zero to time of last quantifiable concentration [AUC(0-T)]
Time frame: Up to approximately 44 days
Incidence of adverse events (AEs)
Time frame: Up to approximately 44 days
Incidence of serious adverse events (SAEs)
Time frame: Up to approximately 44 days
Number of participants with physical examination abnormalities
Time frame: Up to approximately 44 days
Number of participants with vital sign abnormalities
Time frame: Up to approximately 44 days
Number of participants with electrocardiogram (ECG) abnormalities
Time frame: Up to approximately 44 days
Number of participants with clinical safety laboratory test abnormalities
Time frame: Up to approximately 44 days
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