Heat stroke is a life-threatening clinical syndrome characterized by an imbalance between heat production and heat dissipation in the body, resulting from exposure to hot and humid environments and/or strenuous exercise. It is defined by an elevated core temperature exceeding 40°C and central nervous system abnormalities, accompanied by multi-organ dysfunction. The severity of cellular and tissue damage in heat stroke patients depends on the peak temperature reached and the duration of hyperthermia. Rapid reduction of core temperature can halt cellular damage, quickly reverse organ dysfunction, and improve patient outcomes. Therefore, early identification and rapid cooling are crucial to prevent irreversible damage and death in heat stroke patients. However, there is a lack of systematic and specific protocols to guide emergency medical staff in the standardized and effective management of body temperature in heat stroke patients. To address this, our research team previously developed an early in-hospital temperature management protocol for heat stroke patients based on the best available evidence, expert consultations, and expert panel meetings. This study aims to validate the feasibility and effectiveness of the protocol through clinical research, providing a basis for clinical practice.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
188
The early in-hospital temperature management protocol for heat stroke includes early identification, selection of cooling methods for rapid cooling, precise target temperature management, and dynamic monitoring. Effective temperature management will be implemented for heat stroke patients to improve their outcomes.
Yongkang First People's Hospital
Guli, Zhejiang, China
RECRUITINGDongyang People's Hospital
Dongyang, China
RECRUITINGThe Second Affiliated Hospital of Zhejiang University School of Medicine
Hanzhou, China
RECRUITINGJinhua Municipal Central Hospital
Jinhua, China
RECRUITINGJinhua People's Hospital
Jinhua, China
RECRUITINGLanxi People's Hospital
Lanxi, China
RECRUITINGYiwu Central Hospital
Yiwu, China
RECRUITINGcooling rate at 0.5 hours
The cooling rate at 0.5 hours was calculated in reference to initial body temperature and body temperature at 0.5 hours
Time frame: 0.5 hours
Body temperature at 0.5 hours
Body temperature at 0.5 hour refers to a reading obtained 25 to 35 minutes after admission.
Time frame: 0.5 hours
Body temperature at 2 hours
Body temperature at 2 hours refers to a reading taken 100 to 140 minutes after admission
Time frame: 2 hours
in-hospital mortality
Mortality from any cause during hospitalization
Time frame: 30 days
3-month mortality rate
death within 3 months after emergency visit
Time frame: 3 months
Number of participants with other complications
including heart failure, renal failure, coagulation disorders, respiratory failure, neurological sequelae, etc.
Time frame: 3 months
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