Diagnostic Role of Serum Testican and Ubiquitin Levels in Patients With Head Trauma

Kanuni Sultan Suleyman Training and Research Hospital89 enrolled

Overview

We aimed to determine if testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course (presence of intraparenchymal pathology) and mortality in patients with moderate traumatic brain injury.

The study specifically included patients over 18 years of age with moderate TBI (GCS: 9-13) who provided informed consent. The control group consisted of healthy individuals without any disease who voluntarily participated in the study. Patients with moderate TBI were divided into two groups: those with intracranial pathology (Subdural hemorrhage, epidural hemorrhage, subarachnoid hemorrhage, intraparenchymal hemorrhage, and contusion) and those without. Treatment was initiated according to ATLS in patients with moderate TBI, and blood samples taken at the time of admission to the emergency department were placed in Ethylenediaminetetraacetic acid (EDTA) tubes. The relationship between the patient's clinical scoring (GCS, ISS and AIS), brain CT results, and mortality status with testican-1 and ubiquitin levels was compared.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Moderate Traumatic Brain Injury Testican-1 Ubiquitin

Interventions

Testican-1DIAGNOSTIC_TEST

Testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course and mortality in patients with moderate traumatic brain injury.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * being over 18 years old * having a GCS score between 9 and 13 Exclusion Criteria: * under 18 years of age * had missing data * were pregnant * had neurodegenerative disease * had Central Nervous System (CNS) infection * had cerebral palsy * had penetrating head injury (by a cutting or piercing tool such as a firearm, knife, axe) * patients with severe (GCS: 3-8) or mild (GCS: 14-15) TBI

Locations (1)

Kanuni SUltan Suleyman Training and Research Hospital

Istanbul, Küçükçekmece, Turkey (Türkiye)

Outcomes

Primary Outcomes

Comparison of testican-1 and ubiquitin levels in patients with moderate traumatic brain injuries and a control group

We compared the plasma blood levels of biomarkers in both groups

Time frame: The study was conducted with blood samples taken at the time of admission.

Secondary Outcomes

ROC curve analysis for the prediction of intraparenchymal pathology (+)

We investigated the diagnostic value of biomarkers in detecting pathology on brain CT in patients with moderate traumatic brain injury.

Time frame: The study was conducted with blood samples taken at the time of admission.

Data from ClinicalTrials.gov

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