Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Reperfusion Therapy

Inclusion Criteria: 1. Age between 18 and 80 years; 2. Anterior circulation acute ischemic stroke, with acute occlusion of the responsible vessel located in the intracranial segment of the internal carotid artery, or the M1 or M2 segment of the middle cerebral artery; 3. National Institute of Health Stroke Scale (NIHSS) score ≥6; 4. Modified Rankin Scale (mRS) score ≤1 before onset of the disease; 5. Alberta Stroke Program Early CT Score (ASPECTS) ≥3 points; 6. Ischemic-core volume ≤100ml; 7. Patient treatable within 24 hours of symptom onset. Symptoms onset is defined as point in time the patient was last seen well (at baseline) if patients are unable to provide a reliable history or the point in time when symptoms have started if patients can provide a reliable history. Treatment start is defined as groin puncture.; 8. Written informed consent provided by the patients or their legal relatives. Exclusion Criteria: 1. Evidence of intracranial hemorrhage (intracerebral hematoma (ICH), subarachnoid hemorrhage (SAH), epidural hemorrhage, acute or chronic subdural hematoma (SDH)) on the baseline CT or MRI scan； 2. History of congenital or acquired bleeding disorders, coagulation factor deficiency diseases, thrombocytopenic diseases, etc; 3. Anticipated difficulty in completing endovascular treatment due to vascular tortuosity; 4. Known severe allergy (more severe than skin rash) to contrast agents uncontrolled by medications; 5. Pregnancy, breastfeeding； 6. An episode or exacerbation of congestive heart failure from any cause in the past 6 months; 7. History of heart valve disease complicated by congestive heart failure within the past 6 months； 8. Cardiac surgery with thoracotomy (eg coronary artery bypass grafting or valve replacement surgery) within the past 6 months； 9. Acute myocardial infarction in the past 6 months; 10. Signs or symptoms of acute myocardial infarction upon admission, including electrocardiographic findings； 11. Elevated serum troponin concentration upon admission (\>0.1 μg/L) ； 12. Acute arrhythmia (including any tachycardia or bradycardia) with hemodynamic instability (systolic blood pressure \<100 mm Hg) upon admission； 13. Acute or chronic lung diseases requiring long-term or intermittent oxygen therapy； 14. Findings on physical examination of any of the following abnormalities: (1) Jugular venous distension (jugular venous pulsation \>4 cm above the sternal angle); (2) Resting tachycardia due to congestive heart failure (heart rate \> 100 per/min); (3) Third heart sound; (4) Abnormal hepatic jugular venous reflux; (5) Pitting edema of the lower extremities attributable to congestive heart failure or without apparent cause; (6) Rales in both lungs; (7) Or evidence of pulmonary edema, pleural effusion, or pulmonary vascular redistribution on chest X-ray； 15. Known recent or current serum creatinine exceeding 1.5 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \< 60 mL/min; 16. Refractory hypertension that is difficult to control by medication (defined as systolic blood pressure \> 220 mmHg, or diastolic blood pressure \> 110 mmHg); 17. Severe chronic anemia (hemoglobin \< 75 g/L); 18. History of albumin allergy or known allergy to albumin; 19. Patients with severe mental disorders or dementia who are unable to cooperate in completing informed consent and follow-up content; 20. The expected survival time is less than 90 days (such as comorbidity with malignant tumor or severe systemic diseases etc.); 21. Patients who have participated in other interventional clinical studies within 30 days prior to randomization or are currently participating in other interventional clinical studies.