Steps Against the Burden of Parkinson's Disease - StepuP

Tel-Aviv Sourasky Medical Center21 enrolled

Overview

The goals of our StepuP project are: 1. To understand the kinematic and neural mechanisms underlying walking improvements due to treadmill training with and without VR-enabled gait adaptations in people with PD; 2. To assess to what extent improvements in walking due to treadmill training, as measured in the laboratory, transfer to improvements in daily life mobility; 3. To understand the mechanisms underlying the transfer from improvements in walking to improvements in mobility in daily life in people with PD; 4. To understand for whom treadmill training improves walking characteristics in the laboratory and for whom it does not, and to understand for whom treadmill training improves mobility in daily life and for whom it does not.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Parkinson Disease

Interventions

Eligibility

Sex: ALLMin age: 25 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: Specific criteria for Parkinson's disease - PD * Diagnosis of Parkinson's disease according to the MDS World Movement Disorders Society criteria Disease severity H\&Y I-III * Score section 3.10 (ability to walk) MDS-UPDRS 3.10 ≥ 1 * MoCA cognitive assessment \> 15 * Stable cardiovascular condition, ability to perform aerobic activity at low to moderate intensity * Without orthopedic diseases and other diseases that affect the quality of walking, at the decision of the researcher. Exclusion Criteria: * Moderate or severe depression (BDI-II ≥18) * Orthopedic diseases and other diseases that affect the quality of walking, at the decision of the researcher

Outcomes

Primary Outcomes

motion capture

Kinematic data will be collected using a Qualisys or Vicon motion capture system at a sampling frequency of 100 Hz.

Time frame: 13 months

describe brain activity by EEG cap

EEG recordings will be made using a 64-channel or 128 channel EEG cap

Time frame: 13 months

describe muscles activity by EMG electrodes

Bipolar EMG electrodes will be placed on the leg muscles. EMG data will be recorded at a sample frequency available for each system around 2000 Hz.

Time frame: 13 months

Secondary Outcomes

clinical trial TUG

standard time-up-and-go test

Time frame: 13 months

clinical trial walk test

2-minute walk test

Time frame: 13 months

clinical trial MiniBESTest

balance and fall risk

Time frame: 13 months

mGES questionnaire

modified gait efficacy scale

Time frame: 13 months

FES-i questionnaire

Short falls efficacy scale international FES-i

Time frame: 13 months

FACIT-F questionnaire

fatigue

Time frame: 13 months

EQ-5D questionnaire

health-related quality of life

Time frame: 13 months

Frailty questionnaire

Frailty index for physical activity

Time frame: 13 months

Fall questionnaires

Fall events (occurrence and frequency) and fall related injuries. (twelve-month retrospective during T0 and during the duration of the trail

Time frame: 13 months

MDS-UPDRS test

MDS-UPDRS

Time frame: 13 months

NFOGQ questionnaires

NFOGQ

Time frame: 13 months

aids questionnaires

Use of mobility aids

Time frame: 13 months

cognition questionnaires

MoCA and trail making test for cognition

Time frame: 13 months

Demographics questionnaire ( descriptive measures)

General descriptive measures : Year of birth, gender, height, weight, shoe size, education, employment, living arrangement, smoking history and alcohol consumption.

Time frame: 13 months

Fracture history questionnaire

Fracture history (number and type of fracture, twelve-month retrospective of T0)

Time frame: 13 months