In psychiatry, insight is the patient's awareness of his or her disorder or symptom. Lack of insight also seems to be associated with the presence of anxiety-depressive symptoms. There are several forms of insight: * clinical" insight, which is the perception of suffering from a given pathology or symptoms * cognitive insight (CI), which is the ability to analyse or judge one's own thoughts, beliefs and judgements * and the insight of cognitive disorders or the subjective perception of the cognitive alterations (or cognitive symptoms) presented. In this study, the investigators will refer to this dimension as 'subjective cognitive complaint' (SCP), in order to differentiate it from cognitive insight, the name of which may lead to confusion. In schizophrenic disorders, there is a positive correlation between the subjective cognitive complaint SCC, and certain alterations in the neurocognitive assessment, including the attentional dimension. There are scales for collecting SCC in psychotic disorders, such as the SSTICS. To date, there is no scale validated specifically for the UHR population. Thus, the scales used (STICSS, SCoRS, etc.) are validated in populations presenting a characterised psychotic state. Objective impairment is measured during a neurocognitive assessment carried out by a specialised professional: a clinical psychologist specialised in neuropsychology. The cognitive performance of UHR patients is impaired, particularly in terms of cognitive flexibility and self-perception of cognitive disorders, and there may be a discrepancy between the complaint, the objective disorders and their identification as "disorders" by the patient. Despite this discrepancy, to the investigators knowledge no study to date has investigated a possible link between SCC and psychotic transition in this population. Thus, it is not known whether social class may be a factor in exposure to transition, or whether there is a link at all between social class and risk of transition. The aim of this study is to determine psychotic transition in UHR in a 30 months follow-up, and to determine whether there is a link between SCC and transition.
Study Type
OBSERVATIONAL
Enrollment
125
This study is observationnal: Questionnaires to assess the endpoint
Mirvat B HAMDAN-DUMONT
Limoges, France
Percent of Psychotic transition in UHR
Use of the CAARMS scale The section on positive symptoms uses a score of symptom intensity (out of 6 points) and frequency (out of 6 points) to determine whether the patient has reached a threshold of mild psychosis (UHR)
Time frame: 30 months
Assessment of complaints versus absence of complaints in UHRs
Subjective Cognitive Complaint scale score in UHR within 3 months of assessment. The scale is called SSTICS Subjective Scale to Investigate Cognition in Schizphrenia. Minimal score: 0. Maximal score: 84. Higher scores are related to worse outcomes.
Time frame: 3 months
Assessment of attentional impairment versus absence of attentional impairment in UHRs with cognitive complaint
Score at d2R test in the UHR population. d2-R test of attention is a neuropsychological measure of selective and sustained attention and visual scanning speed. The test is computerized. Three main variables are computed and the reported as norm-referenced scores: concentration performance, processed targets and accuracy. Three other variables have only their raw scores reported: errors of omission, errors of commission and errors of commission of "letter" type. Standardized scores consider a test taker's performance in the context of a suitable reference group. The reference group used in this study will be "european population, male and female, 18 - 55 years". The taker's score is plotted as a red line in a graph representing the reference group's performances. Score below 35 is significantly below average. Score over 65 is significantly above average. A higher score is associated with a better outcome.
Time frame: 3 months
Date of psychotic transition in UHR patients
The date of transition will be evaluated based on the CAARMS subscale score between follow-up visits. The CAARMS Comprehensive Assessment of At-Risk Mental States is a semi-structured assessment tool. The positive symptoms scale is graduated 1 to 6. A higher score is associated with more intense and frequent psychotic symptoms, meaning a worse outcome.
Time frame: 30 months
Clinical factors associated with transition in UHR: insight scale BCIS
Score of Beck Cognitive Insight Scale The beck cognitive insight scale is a 15-item self-report consisting of 2 subscales: self- reflectiveness and self-certainty. Overall, cognitive insight is calculated using a composite index, with higher self-reflectiveness relative to self-certainty being indicative of greater cognitive-insight. Composite index scores of three or lower represent low cognitive insight, and ten or above represent good cognitive insight (better outcome).
Time frame: at baseline: day 1
Clinical factors associated with transition in UHR: self -esteem.
Score of Rosenberg self-esteem scale The Rosenberg self-esteem scale ranges from 0 to 30. Scores below 15 suggest low self-esteem. Scores between 15 and 25 are within normal range (better outcome).
Time frame: at baseline: day 1
Clinical factors associated with transition in UHR: depression
Score of Hamilton Depression Scale Hamilton depression rating scale ranges from 0 to 54. Score 10- 13 mild depression, 14 to 17 mild to moderate, \> 17 moderate to severe depression. Higher score means a worse outcome.
Time frame: at baseline: day 1
Difference between three groups (NoP no psychosis, UHR and FEP first episode psychosis): insight scale
Score of Beck Cognitive Insight Scale The beck cognitive insight scale is a 15-item self-report consisting of 2 subscales: self- reflectiveness and self-certainty. Overall, cognitive insight is calculated using a composite index, with higher self-reflectiveness relative to self-certainty being indicative of greater cognitive-insight. Composite index scores of three or lower represent low cognitive insight, and ten or above represent good cognitive insight (better outcome).
Time frame: at baseline: day 1
Difference between three groups (NoP, UHR and FEP): self-esteem.
Score of Rosenberg self-esteem scale The Rosenberg self-esteem scale ranges from 0 to 30. Scores below 15 suggest low self-esteem. Scores between 15 and 25 are within normal range (better outcome).
Time frame: at baseline: day 1
Difference between three groups ((NoP, UHR and FEP): depression.
Score of Hamilton Depression Scale Hamilton depression rating scale ranges from 0 to 54. Score 10- 13 mild depression, 14 to 17 mild to moderate, \> 17 moderate to severe depression. Higher score means a worse outcome.
Time frame: at baseline: day 1
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.