The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients

Farwaniya Hospital5 enrolled

Overview

Case series of 5 ICU patients in Farwaniya Hospital who developed exposure keratitis and a subsequent small corneal perforation between April 2022 and April 2024. The investigators highlight the non-surgical role of OmniLenz® in the treatment of small corneal perforations secondary to exposure keratitis. The inclusion criteria were corneal perforation less than 1mm in size, positive culture \& sensitivity results and showing initial improvement on topical antibiotic eye drops.

The primary outcome measures were healing of the corneal perforation, a negative Seidel test and reformation of the anterior chamber. Secondary outcome measures were improvement of all three of ciliary injection, state of epithelial defect, and corneal infiltration.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Corneal Perforation Exposure Keratitis Infectious Keratitis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion/Exclusion Criteria: * Patients with small corneal perforations measuring \< 1 mm in diameter. Those with larger perforations (\>1mm) were excluded. * Patients with conclusive results of keratitis (confirmed via culture and sensitivity scraping) AND showing improved keratitis following antibiotic treatment. Those with no confirmed keratitis through C\&S or with inconclusive scraping results were excluded. * No age or gender restrictions were applied.

Outcomes

Primary Outcomes

Size of corneal perforation

Size of corneal perforation will be measured in mm using slit lamp examination

Time frame: one week

Secondary Outcomes

size of epithelial defect

Size of epithelial defect will be measured in mm using slit lamp examination