Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral Sclerosis

N/ANot Yet RecruitingNCT06541873

IRCCS San Raffaele60 enrolled

Overview

The investigators hypothesize a relevant impact of cognitive status over gait performance in patients with amyotrophic lateral sclerosis (ALS), contributing to poor mobility and representing a relevant risk for falls. The present observational, cross-sectional study on ambulatory patients with ALS will evaluate gait performance using different sets of dual-task conditions to demonstrate the importance of cognitive aspects in rehabilitation programs for these patients. The dual-task conditions to be assessed during gait performance will include: counting backwards by 3 (executive simple task); counting backwards by 7 (executive complex task); mnemonic recall of the Rey's Auditory Verbal Learning Test (RAVLT). Patients' performance will be compared with a group of healthy controls with similar age and sex distribution in order to highlight the specific effects of the disease.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Amyotrophic Lateral Sclerosis Motor Neuron Disease

Interventions

Clinical and gait evaluation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Patient inclusion criteria: * Age ≥ 18 years; * Clinical diagnosis of ALS or other MND phenotype; * Able to walk unassisted for at least 1 minute consecutively; * Oral and written informed consent to study participation. Healthy control inclusion criteria: 1. Age ≥ 18 years; 2. Age and sex distribution similar to patients (age range: mean age of patients years ± 15 years); 3. Able to walk unassisted for at least 1 minute consecutively; 4. Oral and written informed consent to study participation. Exclusion Criteria An individual (either patient or healthy control) who meets any of the following criteria will be excluded from participation in this study: 1. Diagnosis of dementia; 2. Medical conditions or substance abuse that could interfere with cognition; 3. Any (other) major systemic, psychiatric, neurological, visual, and musculoskeletal disturbances or other causes of walking inability.

Outcomes

Primary Outcomes

Dual-task cost at 1-Minute Walking Test performance

Percentage of variability of gait scores obtained at the 1-Minute Walking Test (1minWT) (i.e., meters walked in one minute) in dual-task vs. single-task conditions in ALS patients compared with healthy controls