This trial aimed to investigate the effects of low-fat and full-fat milk on patients with coronary artery disease (CAD).
The effects of low-fat and full-fat milk on lipid profiles and sphingolipid profiles in CAD patients are not well understood. In addition, milk intake is at a low level in the Chinese population compared with developed countries. Therefore, we aimed to conduct a randomized controlled trial to investigate the effects of low-fat and full-fat milk on lipid profiles, sphingolipid profiles, and cardiac performance in Chinese CAD patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
120
All milk is provided by the Inner Mongolia Yili Industrial Group Limited by Share Ltd (Inner Mongolia, China).
All milk is provided by the Inner Mongolia Yili Industrial Group Limited by Share Ltd (Inner Mongolia, China).
All milk is provided by the Inner Mongolia Yili Industrial Group Limited by Share Ltd (Inner Mongolia, China).
Beijing Chaoyang Hospital Affiliated to Capital Medical University
Beijing, China
Chinese PLA General Hospital
Beijing, China
Dongzhimen Hospital
Beijing, China
The Third Military Medical University of the Chinese people's Liberation Army
Chongqing, China
differences in lipids, sphingolipids, and cardiac function between the three groups after 12 weeks of intervention
The lipids contain total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), small dense LDL (sd LDL), large buoyant LDL (lb LDL), phospholipids, apolipoprotein A Ⅰ (apoA Ⅰ), apolipoprotein B (apoB), and lipoprotein (a). Sphingomyelins (C16:0, C20:0, C20.1:0, C22:0, C24.1:0) as well as their metabolites such as ceramides (C16:0, C18:0, C18.1:0, C20:0, C20.1:0, C22:0, C24:0, C24.1:0), sphingosine, and sphingosine 1-phosphate, were also measured.
Time frame: after 12 weeks of intervention
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The Second Affiliated Hospital of Kunming Medical University
Kunming, China
Nanjing First Hospital
Nanjing, China
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Shanghai, China