Metabolic Syndrome and Related Diseases in Healthcare Workers

Peking Union Medical College Hospital7,432 enrolled

Overview

This study aims to investigate the incidence and prevalence of metabolic syndrome and metabolism-related diseases among healthcare workers, identify potential risk factors for these diseases, evaluate the control status of these conditions, and explore the significance of annual regular check-ups in improving metabolic-related health outcomes. All data for the study subjects are sourced from anonymized continuous records in hospital physical examinations and medical case files. The study does not involve any interventions. Upon obtaining the study data, researchers will use retrospective analysis methods to identify possible associations between risk factors and diseases.

Study Type

OBSERVATIONAL

Enrollment

7,432

Conditions

Metabolic Syndrome X Diabetes Mellitus Type 2 Hypertension Hyperlipidemia Obesity Cardiovascular Diseases Stroke

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years * Healthcare workers who attend annual check-ups at Peking Union Medical College Hospital Exclusion Criteria: * Presence of metabolic syndrome, hypertension, diabetes, coronary heart disease, or stroke at the time of the first physical examination between 2012 and 2022 * Malignant neoplasm * Uremia * Liver failure * Moderate to severe heart failure

Outcomes

Primary Outcomes

composite endpoint of cardiovascular and cerebrovascular diseases

The number of hospitalizations due to severe coronary heart disease, stroke, or sudden cardiac death. The outcome is determined if any of the first three discharge diagnoses include acute myocardial infarction, stroke, or sudden cardiac death, or if an emergency coronary stent placement or coronary artery bypass graft surgery is performed during hospitalization.

Time frame: through study completion, an average of 5 years

Secondary Outcomes

new-onset metabolic syndrome

The number of individuals who did not meet the criteria for metabolic syndrome at the first examination but developed the syndrome later. The diagnostic criteria for metabolic syndrome involve meeting three or more of the following conditions: Abdominal obesity: waist circumference ≥90 (men) or ≥85 (women) cm. Hyperglycemia: fasting blood glucose ≥6.1 or 2-hour postprandial blood glucose ≥7.8 mmol/L or previously diagnosed diabetes. Hypertension: blood pressure ≥130/85 mmHg or previously diagnosed hypertension. Elevated triglycerides: fasting triglycerides ≥1.70 mmol/L or on lipid-lowering medication. Low fasting high-density lipoprotein cholesterol (HDL-C) \<1.04 mmol/L. If waist circumference and HDL-C data are missing, abdominal obesity will be defined using the body mass index (BMI), calculated by dividing weight in kilograms by the square of height in meters (BMI ≥ 28.0 kg/m\^2). Total cholesterol ≥ 5.17 mmol/L will be used as a substitute for the HDL-C indicator.