Long-term Clinical Follow-up After PCI for CTO

University Hospital, Montpellier448 enrolled

Overview

The research aimed to evaluate the impact of a successful Percutaneous coronary intervention of chronic total occlusions (CTO-PCI) on long-term MACE (Major Cardiovascular Events), symptoms, survival, Left Ventricular Ejection Fraction (LVEF) and myocardial ischemia up-to-8-years follow-up.

With this observational and prospective study, this research aimed to evaluate the impact of a successful CTO-PCI on long-term MACE (Major Cardiovascular Events), symptoms, survival, LVEF and myocardial ischemia up-to-8-years follow-up.

Study Type

OBSERVATIONAL

Enrollment

448

Conditions

Coronary Total Occlusion

Interventions

Percutaneous Coronary Intervention of CTOOTHER

CTO-PCI is a procedure of interventional cardiology attempting revascularisation of the CTO

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * who underwent at least one CTO procedure between 2025 and 2022 in Montpellier University Hospital * symptomatic of reversible myocardial ischemia * proof of myocardial viability Exclusion Criteria: * refusal of the patient to participate to the study

Locations (1)

University Hospital

Montpellier, France

Outcomes

Primary Outcomes

Major cardiovascular events (MACE)

Incidence of composite of cardiac death, non-fatal myocardial infarction and new target vessel revascularization

Time frame: Up to 8 years

Secondary Outcomes

Non combined MACE components

Incidence of Cardiac death, non-fatal myocardial infarction and new target vessel revascularization

Time frame: Up to 8 years

In-hospital events

Incidence of Procedural complications including death, periprocedural MI, coronary perforation, pericardial tamponade requiring drainage, local vascular complications, major bleeding, contrast induced nephropathy, stroke

Time frame: Up to one week

Restenosis

Incidence of Restenosis Defined as a greater than 50% diameter stenosis at follow-up angiogram of the first dilated total occlusion. Reocclusion was defined as recurrent total occlusion of the first dilated total occlusion.

Time frame: Up to 8 years

Ischemic burden

Comparison between pre and post-CTO ischemic tests

Time frame: Up to 8 years

Stent thrombosis

Incidence of stent thrombosis defined as any myocardial infarction with angiographic confirmation of in-stent thrombus or unexplained death

Time frame: Within 30 days after the procedure

LVEF

Percentage of Increase or decrease in LVEF after the CTO procedure compared with baseline LVEF

Time frame: Up to 8 years

Data from ClinicalTrials.gov

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