The goal of this retrospective study is to validate a set of computational biomarkers (BioEP) for seizure susceptibility on retrospective routinely collected non-contributory EEGs in paediatric participants with epilepsy. The main objectives are: Primary: To validate a set of computational biomarkers (BioEP) for seizure susceptibility on retrospective routinely collected non-contributory EEGs in paediatric participants with epilepsy. Secondary: To examine whether the use of BioEP could support a more efficient patient pathway to diagnosis (thus adding economic value), by reducing time to final diagnosis and/or the number of clinical appointments needed
Study Type
OBSERVATIONAL
Enrollment
530
All patient's EEG will have the BioEP score conducted on it
Alder Hey Children's NHS Foundation Trust
Liverpool, United Kingdom
Great Ormond Street Hospital for Children
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Maidstone & Tunbridge Wells NHS Trust
Maidstone, United Kingdom
Manchester University NHS Foundation Trust
Manchester, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom
Worcestershire Acute Hospital NHS Trust
Worcester, United Kingdom
To validate a set of computational biomarkers (BioEP) for seizure susceptibility on retrospective routinely collected non-contributory EEGs in paediatric participants with epilepsy.
We shall demonstrate biomarkers from those with epilepsy are distinct from controls by measuring levels of balanced accuracy (sensitivity, specificity, positive predictive ratio, negative predictive ratio, diagnostic odds ratio, and area under operator curve characteristics curve)
Time frame: 1 year
To examine whether the use of BioEP could support a more efficient patient pathway to diagnosis (thus adding economic value), by reducing time to final diagnosis and/or the number of clinical appointments needed
Reduction in time and cost to patients with the use of BioEP
Time frame: 1 year
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