There are currently no clinical and laboratory data that well characterize this neutropenia associated with the Duffy-null phenotype, particularly for pediatric subjects. In particular there are no data on the frequency of immune neutropenia in DANC neutropenic pediatric subjects. The goal of this study is to : * define the frequency of immune neutropenia within the cohort of DANC subjects under study * evaluate the frequency of different degrees of neutropenia (mild-moderate-severe); * evaluate the possible association between different degrees of neutropenia and the presence of infections.
Study Type
OBSERVATIONAL
Enrollment
150
Retrospective collection of clinical and laboratory data relating to the definition of the nature of neutropenia
Fondazione IRCCS Ca' Granda Ospedale Maggioe Policlinico
Milan, Milano, Italy
RECRUITINGImmune neutropenia and DANC
Frequency of immune neutropenia, expressed as the percentage of DANC subjects testing positive for anti-neutrophil antibodies out of the total DANC subjects included in the study.
Time frame: Through study completion, an average of 1 year
Distribution of mild, moderate and severe neutropenia in DANC children
Frequencies in percentage of mild (1000-1500 neutrophils/ul), moderate (500-1000 neutrophils/ul) and severe (\<500 neutrophils/ul) neutropenia within the DANC cohort under study
Time frame: Through study completion, an average of 1 year
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