The investigators design an observational multi-center cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese hospitalized adult patients with primary intracerebral hemorrhage.
This cohort was an analysis based on patients from six stroke centers: the 2nd Affiliated Hospital of Zhejiang University; the First People's Hospital of Pinghu, Jiaxing; the First People's Hospital of Taizhou; the People's Hospital of Haiyan, Jiaxing; Tiantai County People's Hospital, Taizhou; the 2nd People's Hospital of Quzhou (Please see more information of this cohort in supplement). All hospitals are located in Zhejiang Province. Patients' data were entered by local trained registrars using standardised protocols, and the overall process of case registration, monitoring of the data quality, and inquiry and correction of erroneous data was managed and supervised by a steering committee. We included adult patients who (1) admitted for primary ICH ; (2) underwent blood routine test (hemoglobin included) and CT scan as soon as they arrived at hospital; (3) were not treated with neurosurgical procedures. We excluded patients who (1) had ICH secondary to known causes, including trauma, intracranial neoplasm and systemic diseases12, as well as anticoagulative agents; or had isolated intraventricular hemorrhage (IVH); (2) mRS \>2 before the current ICH episode (according to past medical records or description from guardians. This study was approved by human research ethic committees at all participating centers, and conducted in compliance with the principles set forward by the Declaration of Helsinki.
Study Type
OBSERVATIONAL
Enrollment
25,000
The Second Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China
RECRUITINGAll-cause death
Patients die of any reasons
Time frame: 5 years after ICH
ICH recurrence
Patients had an another ICH after this ictus
Time frame: 5 years after ICH
3-month outcome
3-month outcome is measured using modified Rankin Scale (mRS) score
Time frame: 3 months after ICH
hematoma volume
The volume of hematoma according to CT scan at the baseline when patients arrived at the emergency room
Time frame: up to 5 hours (A few hours after ICH)
hematoma expansion
Patients had another CT scan during 24-48 hours after the first CT, and hematoma volume growth exceeding 33% or absolute hematoma growth exceeding 6ml
Time frame: within 48 hours after ICH
cerebral small vessel diseases (CSVDs)
cerebral small vessel diseases evaluated by MRI, including cortical superficial siderosis (cSS), white matter hyperintensity (WMH), cerebral microbleed (CMB), etc.
Time frame: within 2 weeks after ICH
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