A Phase I Study of GZR18 Injection in Obese/Overweight Subjects

Inclusion Criteria: * Subjects sign the informed consent form (ICF) voluntarily. * Chinese adult subjects, both male and female. * 18 to 65 years old (including both ends) at screening. * BMI≥26.0 kg/m2 at screening. * Stable weight before screening (i.e. self-reported weight change less than 5 kg within 8 weeks before screening). * Female subjects have negative serum Human Chorionic Gonadotropin (HCG) during screening and baseline periods. * Subjects have good daily habits and can maintain good communication with investigators and comply with various requirements of clinical trials. Exclusion Criteria: * Lactating women. * History of fainting with blood and needles. * Known or suspected allergy to study related products; or drug/food allergy history; or allergy-related diseases history. * Subjects who have participated in other clinical trials and given investigational drugs or medical device interventions within 90 days before screening. * History of drug abuse within 1 year before screening, or positive results in drug abuse screening (urine). * Smokers who smoke ≥ 5 cigarettes per day within the previous 3 months before screening or cannot refrain from smoking throughout the trial period. * Any vaccine has been used within 28 days before administration, as well as any vaccine that may be used throughout the trial period. * Other scenarios judged by the investigator to render the subjects unsuitable for participating in this study.