A Phase I Study of GZR18 Injection in Healthy Subjects

Inclusion Criteria: * 1\. Subjects sign informed consent voluntarily. * 2\. Chinese adult subjects, male or female. * 3\. Age 18-55 at screening (both included). * 4\. At screening and baseline, 19.0 kg/m2 ≤ BMI ≤ 26.0 kg/m2 (male ≥55.0 kg, female ≥45.0 kg). * 5\. Female subjects were human chorionic gonadotophin (HCG) negative at screening and baseline. Exclusion Criteria: * 1\. History of dizziness with blood and needles. * 2\. Known or suspected allergy to study related products; or a history of drug and food allergies; or a history of allergy-related diseases. * 3\. Participants who participated in other clinical trials and were given the investigational drug or medical device intervention within 90 days prior to screening. * 4\. Blood donation, surgery, or trauma with significant blood loss (more than or equal to 400 mL, except for menstrual blood loss in women) within 12 weeks prior to screening. * 5\. Any clinically significant medical history judged by the investigator, including but not limited to: lung, gastrointestinal, liver, nervous system, kidney, genitourinary and endocrine, skin, or blood disorders, especially a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 , and a history of pancreatitis (acute or chronic). * 6\. At screening or baseline, physical examination showed clinically significant abnormalities judged by the investigator.