Danish Breast Cancer Group Internal Mammary Node Study

N/AActive Not RecruitingNCT06549920

Danish Breast Cancer Cooperative Group7,630 enrolled

Overview

The DBCG IMN study is a nationwide prospective population-based cohort study allocating node-positive breast cancer patients with right-sided tumors to internal mammary node irradiation (IMNI) and patients with left-sided tumors to no IMNI.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

7,630

Conditions

Breast Cancer

Interventions

Internal mammary node irradiationRADIATION

Irradiation of the internal mammary nodes in intercostal space 1-4.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with macrometastatic node-positive breast cancer treated with loco-regional radiotherapy. Exclusion Criteria: * Prior malignancies, bilateral breast cancer, neoadjuvant systemic therapy, recurrence before radiotherapy, and non-standard radiotherapy.

Outcomes

Primary Outcomes

Overall survival

Censored at end of study or by emigration.

Time frame: 15-years.

Secondary Outcomes

Breast cancer mortality

Censored at end of study or by emigration.

Time frame: 15-years.

Distant recurrences

Censored at end of study or by emigration. Death by any cause was regarded as competing event.

Time frame: 15-years.

Data from ClinicalTrials.gov

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