DCB vs. DES in Bifurcation Coronary Lesions

Inclusion Criteria: * Subject must be age ≥18 years. * Subject has silent ischemia, or stable/unstable angina, or acute MI older than 1-week from the onset of chest pain to admission. * Subject understands the trial design and treatment procedures and provides written informal consent before entering the trial * Subject is willing to comply with all protocol-required follow-up evaluations. * Target lesion must be native non-LM bifurcation lesion * Target lesion must be a bifurcation lesion on coronary angiography (defined as Medina 0,1,1, Medina 1,0,1, Medina 1,1,1 or Medina 0,0,1 coronary bifurcation lesions) and is eligible for percutaneous coronary intervention (PCI). * Target lesion reference vessel diameter (both main vessel and side branch) * 2.0 mm by visual estimation. * Target lesion must have visually estimated stenosis ≥50%. * Target lesion length of side branch must be \<25 mm by visual estimation. Exclusion Criteria: * Patient with STEMI (within 3 days from the onset of chest pain to coronarography). * Patient has known allergy to the study balloon/stent system. * Patient has any other serious medical illness that may reduce life expectancy to less than 12 months. * Patient is pregnant or nursing. * Patient is participating in another clinical trial that has not reached its primary endpoint within 24 months after the index procedure. * Patient has a planned procedure that may cause non-compliance with the protocol or confound data interpretation. * In-stent restenosis lesion. * Chronic total occlusion (CTO) lesion in either main vessel or side branch. * Left ventricular ejection fraction \<30%; * Visible and untreatable thrombus at lesion site; * Target lesion/vessel with any of the following characteristics: * Severe and/or \>270° calcification of the target vessel, also proximal to the lesion (intravascular imaging); * Bifurcation lesion where stent strategy is anticipated; * Left main stem stenosis \>50%; * Target lesion is in the left main stem; * Lesions length \>50 mm (main vessel) * Lesions length \>25 mm (side branch)